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D-色氨酸

D-色氨酸用途

H-D-Trp-OH 是色氨酸的 D 型异构体,它偶尔也会在自然界多肽中被发现,如海洋毒肽。

D-色氨酸名称

[ CAS 号 ]:
153-94-6

[ 中文名 ]:
D-色氨酸

[ 英文名 ]:
D-tryptophan

[中文别名 ]:

[英文别名 ]:

(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
(R)-a-Amino-3-indolepropionic Acid
Tryptophan
H-D-Trp-OH
(R)-a-Aminoindole-3-propanoic Acid
EINECS 205-819-9
D-α-Amino-3-indolepropionic acid
(R)-tryptophan
D-tryptophan
D-tryptophan zwitterion

D-色氨酸生物活性

[ 描述 ]:

H-D-Trp-OH 是色氨酸的 D 型异构体,它偶尔也会在自然界多肽中被发现,如海洋毒肽。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

D-色氨酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
447.9±35.0 °C at 760 mmHg

[ 熔点 ]:
282-285ºC

[ 分子式 ]:
C₁₁H₁₂N₂O₂

[ 分子量 ]:
204.225

[ 闪点 ]:
224.7±25.9 °C

[ 精确质量 ]:
204.089874

[ PSA ]:
79.11000

[ LogP ]:
1.04

[ 外观性状 ]:
白色或黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.698

[ 储存条件 ]:
室温

D-色氨酸MSDS

D-色氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6129000

CHEMICAL NAME :: Tryptophan, D-

CAS REGISTRY NUMBER :: 153-94-6

LAST UPDATED :: 199803

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H12-N2-O2

MOLECULAR WEIGHT :: 204.25

WISWESSER LINE NOTATION :: T56 BMJ D1YZVQ -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4289 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5536 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 307 (estimated) No. of Female Employees: 251 (estimated)

D-色氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YN6129000

[ 海关编码 ]:
2933990090

D-色氨酸合成路线

D-色氨酸上下游产品

D-色氨酸上游产品

D-色氨酸下游产品

D-色氨酸制备

以DL-色氨酸为原料，冷却状态下加入氯乙酸酐反应，经硫酸酸化后在冰水中研磨，过滤后水中重结晶，最后用胰羧肽酶处理，除去L-型，乙酸酸化、乙醇重结晶精制而得。

D-色氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

D-色氨酸文献

Enantioseparation of (DL)-tryptophan by spiral tube assembly counter-current chromatography and evaluation of mass transfer rate for enantiomers.

J. Chromatogr. A. 1374 , 77-84, (2014)

Spiral tube assembly counter-current chromatography was successfully applied in enantioseparation of dl-tryptophan using bovine serum albumin as chiral selector. An improved biphasic aqueous-aqueous s...

Inhibition of Pseudomonas aeruginosa biofilm formation on wound dressings.

Wound Repair Regen. 23 , 842-54, (2015)

Chronic nonhealing skin wounds often contain bacterial biofilms that prevent normal wound healing and closure and present challenges to the use of conventional wound dressings. We investigated inhibit...

Carbonic anhydrase activators: activation of the human tumor-associated isozymes IX and XII with amino acids and amines.

Bioorg. Med. Chem. 16 , 3530-6, (2008)

The first activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms associated to tumors, hCA IX and XII, with a small library of natural and non-natural amino acids as well as aroma...

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