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可托多松

可托多松用途

Cortodoxone是一种糖皮质类固醇激素，可氧化为皮质醇 (Hydrocortisone) 。

可托多松名称

[ CAS 号 ]:
152-58-9

[ 中文名 ]:
脱氧可的松

[ 英文名 ]:
Cortodoxone

[中文别名 ]:

[英文别名 ]:

11-deoxy-17-hydroxy-Corticosterone
CORTEXOLONE
17-Hydroxy-11-desoxy-corticosterone
SK&F 3050
4-Pregnene-17α,21-diol-3,20-dione
11-Deoxycortisol
11-deoxy-Cortisol
17α,21-Dihydroxy-4-pregnene-3,20-dione
11-dioxy-cortiso
Reichstein S

可托多松物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
524.5±50.0 °C at 760 mmHg

[ 熔点 ]:
205-208 °C

[ 分子式 ]:
C₂₁H₃₀O₄

[ 分子量 ]:
346.461

[ 闪点 ]:
285.1±26.6 °C

[ 精确质量 ]:
346.214417

[ PSA ]:
74.60000

[ LogP ]:
2.74

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.578

[ 储存条件 ]:
-20°C Freezer

可托多松MSDS

详细MSDS(安全技术说明书)

可托多松毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5011500

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17,21-dihydroxy-

CAS REGISTRY NUMBER :: 152-58-9

BEILSTEIN REFERENCE NO. :: 2511358

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H30-O4

MOLECULAR WEIGHT :: 346.51

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1Q FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

可托多松安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
R22;R24/25

[ 安全声明 (欧洲) ]:
S24/25-S22

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS号 ]:
TU5011500

可托多松上下游产品

可托多松上游产品

可托多松下游产品

可托多松制备

可由肾上腺提取液分离，也可由胆汁酸、山药皂草苷等制得。

可托多松文献

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).

J. Med. Chem. 48 , 3269-79, (2005)

Growing interest in the use of both the logarithm of the partition coefficient of the neutral species in the alkane/water system (log P(N)(alk)) and the difference between log P(N)(oct) (the logarithm...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

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