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NE 100 hydrochloride

NE 100 hydrochloride用途

NE-100(盐酸盐)是一种有效的选择性sigma-1受体拮抗剂,IC50为4.16 nM。NE-100(盐酸)在体内发挥抗精神病活性[1]。NE-100(盐酸)也能抑制内质网应激诱导的海马细胞死亡[2]。

NE 100 hydrochloride名称

[ CAS 号 ]:
149409-57-4

[ 英文名 ]:
NE 100 hydrochloride

[英文别名 ]:

ne 100
NE-100

NE 100 hydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90.

[2]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9.

NE 100 hydrochloride物理化学性质

[ 沸点 ]:
475.2ºC at 760 mmHg

[ 分子式 ]:
C₂₃H₃₄ClNO₂

[ 分子量 ]:
391.97500

[ 闪点 ]:
137.4ºC

[ 精确质量 ]:
391.22800

[ PSA ]:
21.70000

[ LogP ]:
5.78320

[ 蒸汽压 ]:
3.37E-09mmHg at 25°C

[ 储存条件 ]:
-20°C，密闭，干燥

NE 100 hydrochlorideMSDS

详细MSDS(安全技术说明书)

NE 100 hydrochloride安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

NE 100 hydrochloride文献

Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes.

Am. J. Physiol. Heart Circ. Physiol. 305(8) , H1201-12, (2013)

Although pentazocine binds to σ1-receptor (σ1R) with high affinity, the physiological relevance of its binding remains unclear. We first confirmed that σ1R stimulation with pentazocine rescues contrac...

A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells

Biochem. Biophys. Res. Commun. 434(4) , 904-9, (2013)

Highlights • NE-100 protected neuronal cells against the tunicamycin-induced cell death. • NE-100 attenuated the upregulation of CHOP induced by ER stress. • NE-100 upregulated the expressions of p50A...

Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model.

Curr. Drug Metab. 7(2) , 135-46, (2006)

The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2...

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