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β-紫罗兰酮

β-紫罗兰酮用途

β-Ionone 可从植物油中分离,可有效诱导胃腺癌细胞 SGC7901 凋亡 (apoptosis)。具有抗肿瘤活性。

β-紫罗兰酮名称

[ CAS 号 ]:
14901-07-6

[ 中文名 ]:
乙位紫罗兰酮

[ 英文名 ]:
β-Ionone

[中文别名 ]:

[英文别名 ]:

Beta-Ionone
MFCD00001549
β-Ionone
EINECS 201-224-3
beta-Ionone,synthetic
trans-b-Ionone
(E)-b-Ionone
trans-β-Ionone

β-紫罗兰酮生物活性

[ 描述 ]:

β-Ionone 可从植物油中分离,可有效诱导胃腺癌细胞 SGC7901 凋亡 (apoptosis)。具有抗肿瘤活性。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[体外研究]

β-紫罗兰酮是β-类胡萝卜素的类似物,广泛分布于水果和蔬菜中[1]。β-紫罗兰酮(25、50、100和200μM；作用24和48h)可抑制SGC-7901细胞生长。测量值为IC89μM。

[参考文献]

[1]. Mahsa Ansari, et al. β-Ionone and Its Analogs as Promising Anticancer Agents. Eur J Med Chem. 2016 Nov 10;123:141-154.

β-紫罗兰酮物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
254.8±0.0 °C at 760 mmHg

[ 熔点 ]:
-49ºC

[ 分子式 ]:
C₁₃H₂₀O

[ 分子量 ]:
192.297

[ 闪点 ]:
121.3±11.9 °C

[ 精确质量 ]:
192.151413

[ PSA ]:
17.07000

[ LogP ]:
3.85

[ 外观性状 ]:
透明至淡黄色液体,带有紫罗兰的气味

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.518

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
SLIGHTLY SOLUBLE

β-紫罗兰酮MSDS

详细MSDS(安全技术说明书)

β-紫罗兰酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EN0350000

CHEMICAL NAME :: 3-Buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-

CAS REGISTRY NUMBER :: 14901-07-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H20-O

MOLECULAR WEIGHT :: 192.33

WISWESSER LINE NOTATION :: L6UTJ A1U1V1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4590 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2277 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 44A,48,1967 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6663 No. of Facilities: 1930 (estimated) No. of Industries: 18 No. of Occupations: 19 No. of Employees: 27288 (estimated) No. of Female Employees: 7053 (estimated)

β-紫罗兰酮安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R38;R51/53

[ 安全声明 (欧洲) ]:
61-36/37/39-27-26

[ 危险品运输编码 ]:
UN 3082

[ WGK德国 ]:
2

[ RTECS号 ]:
EN0500000

[ 包装等级 ]:
II; III

[ 危险类别 ]:
4.1

[ 海关编码 ]:
2914399090

β-紫罗兰酮制备

1. 由柠檬醛与丙酮在稀苛性碱溶液中缩合。再用硫酸或磷酸环化而制得。

β-紫罗兰酮海关

[ 海关编码 ]: 2914399090

[ 中文概述 ]:
2914399090. 其他不含其他含氧基的芳香酮. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%