roridin a

roridin a用途

Roridin A是拟南芥花粉发育的抑制剂。Roridin A是从真菌Cylindrocarpon sp.中分离出来的。Roridin A在浓度为2μM时抑制花粉发育[1]。

roridin a名称

[ CAS 号 ]:
14729-29-4

[ 中文名 ]:
7'-去氧代-7'-[(1R)-1-羟基乙基]-(7'R)-疣孢菌素 A

[ 英文名 ]:
roridin a

[英文别名 ]:

roridin a生物活性

[ 描述 ]:

Roridin A是拟南芥花粉发育的抑制剂。Roridin A是从真菌Cylindrocarpon sp.中分离出来的。Roridin A在浓度为2μM时抑制花粉发育[1]。

[ 相关类别 ]:

研究领域 >> 其他
信号通路 >> 其他 >> 其他

[参考文献]

[1]. AtsumiShimada, et al. Roridin A and verrucarin A, inhibitors of pollen development in Arabidopsis thaliana, produced by Cylindrocarpon sp.

roridin a物理化学性质

[ 密度 ]:
1.29g/cm3

[ 沸点 ]:
752.4ºC at 760 mmHg

[ 分子式 ]:
C29H40O9

[ 分子量 ]:
532.62200

[ 闪点 ]:
246ºC

[ 精确质量 ]:
532.26700

[ PSA ]:
124.05000

[ LogP ]:
2.39340

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
3.92E-26mmHg at 25°C

[ 折射率 ]:
1.58

roridin a毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VL0355000
CHEMICAL NAME :
Roridin A
CAS REGISTRY NUMBER :
14729-29-4
LAST UPDATED :
198708
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C29-H40-O9
MOLECULAR WEIGHT :
532.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIBIAU Biotechnology and Bioengineering. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.4- 1962- Volume(issue)/page/year: 10,445,1968
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
2300 ug/kg
TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from large intestine Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 23,731,1985

roridin a安全信息

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R28

[ 安全声明 (欧洲) ]:
28-36/37-45

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ 危险类别 ]:
6.1(a)

roridin a合成路线

详细合成路线

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