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去氢胆酸钠

去氢胆酸钠用途

Dehydrocholic钠是一种胆液排泄增多剂, 增加胆汁输出, 以清除增加的胆汁酸负载。

去氢胆酸钠名称

[ CAS 号 ]:
145-41-5

[ 中文名 ]:
去氢胆酸钠

[ 英文名 ]:
sodium dehydrocholate

[中文别名 ]:

[英文别名 ]:

Dycholium
Dehydrocholic acid sodium salt
Biliton
Biliron
3,7,12-Trioxo-5b-cholan-24-oic Acid Sodium Salt
Natriumdehydrocholat
Decholin sodium salt
sodium dehydrocholate
(5b)-3,7,12-Trioxocholan-24-oic Acid Sodium Salt
SodiuMDehydrocholic

去氢胆酸钠生物活性

[ 描述 ]:

Dehydrocholic钠是一种胆液排泄增多剂, 增加胆汁输出, 以清除增加的胆汁酸负载。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

去氢胆酸钠物理化学性质

[ 沸点 ]:
581.5ºC at 760mmHg

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₂₄H₃₃NaO₅

[ 分子量 ]:
424.506

[ 闪点 ]:
319.5ºC

[ 精确质量 ]:
424.222565

[ PSA ]:
91.34000

[ LogP ]:
2.73860

[ 外观性状 ]:
固体;White to Light yellow to Light orange powder to crystal

[ 折射率 ]:
27 ° (C=5, H2O)

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
H2O: 0.1 M at 20 °C, clear, colorless

去氢胆酸钠MSDS

详细MSDS(安全技术说明书)

去氢胆酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ2500000

CHEMICAL NAME :: 5-beta-Cholan-24-oic acid, 3,7,12-trioxo-, sodium salt

CAS REGISTRY NUMBER :: 145-41-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C24-H33-O5.Na

MOLECULAR WEIGHT :: 424.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3755 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2630169

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 5,188,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 887 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,280,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: YOIZA3 Yonago Igaku Zasshi. Journal of the Yonago Medical Association. (c/o Tottori Daigaku Igakabu, 86 Nishi-machi, Yonago, Japan) V.1- 1948- Volume(issue)/page/year: 25,70,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Cardiac - other changes Gastrointestinal - other changes Blood - other changes

REFERENCE :: ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS. Volume(issue)/page/year: 52,779,1926

去氢胆酸钠安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S36

[ WGK德国 ]:
3

[ RTECS号 ]:
FZ2500000