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苯酚红

苯酚红用途

酚红(酚磺酞)是一种pH指示染料,在出现阳性反应时,依赖于从粉红色到黄色的明显颜色变化[1][2]。

苯酚红名称

[ CAS 号 ]:
143-74-8

[ 中文名 ]:
酚红

[ 英文名 ]:
Phenol red

[中文别名 ]:

[英文别名 ]:

Phenolsulfonphthalein
P.S.P.
PSP
EINECS 205-609-7
TF-R 2
Phenol red
MFCD00003552

苯酚红生物活性

[ 描述 ]:

酚红(酚磺酞)是一种pH指示染料,在出现阳性反应时,依赖于从粉红色到黄色的明显颜色变化[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

酚红(PR)是各种细胞和组织培养基中的标准pH指示剂,因为它可以快速检查培养物的健康状况。酚红还被用于多种方案,以检测细胞过氧化氢以及人类过氧化物酶的过氧化物酶活性[1]。

[参考文献]

[1]. Morgan A, et al. Caution for the routine use of phenol red - It is more than just a pH indicator. Chem Biol Interact. 2019;310:108739.

[2]. Peltzer D, et al. Rapid and simple colorimetric loop-mediated isothermal amplification (LAMP) assay for the detection of Bovine alphaherpesvirus 1. J Virol Methods. 2021;289:114041.

苯酚红物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
562.8±50.0 °C at 760 mmHg

[ 熔点 ]:
300 °C

[ 分子式 ]:
C₁₉H₁₄O₅S

[ 分子量 ]:
354.376

[ 闪点 ]:
294.2±30.1 °C

[ 精确质量 ]:
354.056183

[ PSA ]:
92.21000

[ LogP ]:
3.02

[ 外观性状 ]:
红色至暗红色结晶粉末

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.697

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
0.77 g/L

苯酚红MSDS

苯酚红毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ7490000

CHEMICAL NAME :: Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)di-, S,S-dioxide

CAS REGISTRY NUMBER :: 143-74-8

BEILSTEIN REFERENCE NO. :: 0326470

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H14-O5-S

MOLECULAR WEIGHT :: 354.39

WISWESSER LINE NOTATION :: T56 BSWO DHJ DR DQ& DR DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 752 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1368 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 1 mg/plate

REFERENCE :: AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 42,641,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82224 No. of Facilities: 1719 (estimated) No. of Industries: 16 No. of Occupations: 13 No. of Employees: 5387 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82224 No. of Facilities: 2166 (estimated) No. of Industries: 19 No. of Occupations: 26 No. of Employees: 27087 (estimated) No. of Female Employees: 14345 (estimated)

苯酚红安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SJ7490000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29349990

苯酚红合成路线

苯酚红上下游产品

苯酚红上游产品

苯酚红下游产品

苯酚红制备

1.将邻磺基苯甲酸酐与苯酚共热熔化，加入无水氯化锌于135-140℃反应7h，然后将缩合物倒入热水中，用滤，用水洗涤固体，进一步用酸碱沉淀法提纯而得成品。

2.将邻磺酰苯甲酰酐和苯酚混合物共热使之完全熔化，当温度为130℃时，加入无水氯化锌于135～140℃反应7h：

反应结束后，加水加热至沸，不断搅拌至苯酚气味消失，离心甩干，用水洗涤沉淀二次。然后加入10%碳酸钠，加热、静置、过滤、水洗沉淀二次，滤液中缓慢加入稀盐酸，搅拌加热至60～80℃，冷却后的沉淀用水洗后并入上述处理过的沉淀中，离心甩干后干燥即可。

苯酚红海关

[ 海关编码 ]: 2934991000

[ 中文概述 ]:
2934991000. 磺内酯及磺内酰胺. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

苯酚红文献

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

Cancer Res. 75(6) , 1102-12, (2015)

The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor of eIF4E funct...

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Drug Des. Devel. Ther. 9 , 1555-84, (2015)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN823...

Methionine oxidation accelerates the aggregation and enhances the neurotoxicity of the D178N variant of the human prion protein.

Biochim. Biophys. Acta 1842(12 Pt A) , 2345-56, (2014)

The D178N mutation of the prion protein (PrP) results in the hereditary prion disease fatal familial insomnia (FFI). Little is known regarding the effects of methionine oxidation on the pathogenesis o...

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苯酚红