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美睾酮

美睾酮用途

【用途一】
用于治疗男性性腺功能减退及精子减少性不育症

美睾酮名称

[ CAS 号 ]:
1424-00-6

[ 中文名 ]:
美睾酮

[ 英文名 ]:
Mesterolone

[中文别名 ]:

[英文别名 ]:

17β-Hydroxy-1α-methyl-5α-androstan-3-one
EINECS 215-836-3
4,5a-Dihydro-1a-methyltestosterone
1a-Methyl-5a-dihydrotestosterone
(1a,5a,17b)-17-Hydroxy-1-methylandrostan-3-one
Proviron
1a-Methyl-5a-androstan-17b-ol-3-one
17b-Hydroxy-1a-methyl-5a-androstan-3-one
5α-Androstan-3-one, 17β-hydroxy-1α-methyl-
Mesterolone

美睾酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
420.3±45.0 °C at 760 mmHg

[ 熔点 ]:
208 °C

[ 分子式 ]:
C₂₀H₃₂O₂

[ 分子量 ]:
304.467

[ 闪点 ]:
179.4±21.3 °C

[ 精确质量 ]:
304.240234

[ PSA ]:
37.30000

[ LogP ]:
4.24

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.525

[ 储存条件 ]:
2-8°C

美睾酮MSDS

美睾酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8063400

CHEMICAL NAME :: 5-alpha-Androstan-3-one, 17-beta-hydroxy-1-alpha-methyl-

CAS REGISTRY NUMBER :: 1424-00-6

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H32-O2

MOLECULAR WEIGHT :: 304.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 600 ug/kg

SEX/DURATION :: female 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,455,1966

美睾酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S22-S24/25-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
BV8063400

[ 海关编码 ]:
2942000000

美睾酮合成路线

美睾酮上下游产品

美睾酮上游产品

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美睾酮海关

[ 海关编码 ]: 2942000000

美睾酮文献

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

J. Med. Chem. 51 , 2047-56, (2008)

A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data s...

Screening for anabolic steroids in urine of forensic cases using fully automated solid phase extraction and LC-MS-MS.

J. Anal. Toxicol. 38(9) , 637-44, (2014)

A screening method for 18 frequently measured exogenous anabolic steroids and the testosterone/epitestosterone (T/E) ratio in forensic cases has been developed and validated. The method involves a ful...

Osteoporosis in male hypogonadism: responses to androgen substitution differ among men with primary and secondary hypogonadism.

Horm. Res. 60(1) , 21-8, (2003)

No randomized study exists comparing the effects of different modes of androgen substitution on bone mineral density (BMD).We performed a prospective, randomized, trial assigning 53 hypogonadal men to...

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美睾酮