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四氢叶酸

四氢叶酸用途

L-5,6,7,8-Tetrahydrofolic acid 是一种叶酸衍生物,是氨基酸和核酸代谢等反应中的一种辅酶。

四氢叶酸名称

[ CAS 号 ]:
135-16-0

[ 中文名 ]:
四氢叶酸

[ 英文名 ]:
L-5,6,7,8-Tetrahydrofolic acid

[中文别名 ]:

四氫葉酸

[英文别名 ]:

Tetrahydrofolic acide
Tetrahydropteroylglutaamic acid
(6S)-Tetrahydrofolic acid
l-amino)benzoyl)
TETRAHYDROFOLIC ACID
EINECS 205-181-1
5,6,7,8-tetrahydrofolicacid
L-5,6,7,8-Tetrahydrofolic acid
MFCD00135583
(6S)-Thfa

四氢叶酸生物活性

[ 描述 ]:

L-5,6,7,8-Tetrahydrofolic acid 是一种叶酸衍生物,是氨基酸和核酸代谢等反应中的一种辅酶。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

四氢叶酸物理化学性质

[ 密度 ]:
1.7g/cm3

[ 沸点 ]:
555.12°C (rough estimate)

[ 分子式 ]:
C₁₉H₂₃N₇O₆

[ 分子量 ]:
445.42900

[ 精确质量 ]:
445.17100

[ PSA ]:
211.56000

[ LogP ]:
1.03910

[ 外观性状 ]:
powder | off-white to tan

[ 折射率 ]:
1.762

[ 储存条件 ]:
−20°C

[ 稳定性 ]:
We have observed that this material decomposes steadily over time. Use immediately upon receipt.

四氢叶酸MSDS

四氢叶酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA0600800

CHEMICAL NAME :: Glutamic acid, N-(p-(((2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridi nyl)methyl)amino) benzoyl)-, L-

CAS REGISTRY NUMBER :: 135-16-0

LAST UPDATED :: 199707

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H23-N7-O6

MOLECULAR WEIGHT :: 445.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 gm/kg/5W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1104,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6 gm/kg/6D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1128,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 46800 mg/kg/26W-I

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1114,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - physical

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973

四氢叶酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MA0600800

[ 海关编码 ]:
2933990090

四氢叶酸合成路线

四氢叶酸上下游产品

四氢叶酸上游产品

四氢叶酸下游产品

四氢叶酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

四氢叶酸文献

Quantitation of 5-Methyltetrahydrofolic Acid in Dried Blood Spots and Dried Plasma Spots by Stable Isotope Dilution Assays.

PLoS ONE 10 , e0143639, (2015)

Because of minimal data available on folate analysis in dried matrix spots (DMSs), we combined the advantages of stable isotope dilution assays followed by LC-MS/MS analysis with DMS sampling to devel...

Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.

Exp. Parasitol. 149 , 16-23, (2015)

Serine hydroxymethyltransferase belongs to the class of pyridoxal-5-phosphate enzymes along with aspartate aminotransferase. To explore the function of residue(s) involved in binding of the carboxylat...

Folate levels measured by LC-MS/MS in patients with colorectal cancer treated with different leucovorin dosages.

Cancer Chemother. Pharmacol. 74(6) , 1167-74, (2014)

Calcium folinate (leucovorin), which is converted in vivo into biologically active folate, enhances the potency of 5-fluorouracil (5-FU)-based chemotherapy in colorectal cancer. A common dosage of leu...

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