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氢氟噻嗪

氢氟噻嗪用途

氢氟甲噻嗪是一种口服有效的噻嗪类利尿剂。氢氟甲肼具有直接刺激正常和四氧嘧啶糖尿病胰腺中细胞分泌的能力[1][2][3]。

氢氟噻嗪名称

[ CAS 号 ]:
135-09-1

[ 中文名 ]:
氢氟噻嗪

[ 英文名 ]:
hydroflumethiazide

[中文别名 ]:

[英文别名 ]:

EINECS 205-173-8
Robezon
Spandiuril
Saluron
MFCD00057316
hydroflumethyazide
Glomerulin
hydroflumenthiazide
Diurometon
hydroflumethiazide

氢氟噻嗪生物活性

[ 描述 ]:

氢氟甲噻嗪是一种口服有效的噻嗪类利尿剂。氢氟甲肼具有直接刺激正常和四氧嘧啶糖尿病胰腺中细胞分泌的能力[1][2][3]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7.

[2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37.

[3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9.

氢氟噻嗪物理化学性质

[ 密度 ]:
1.678g/cm3

[ 沸点 ]:
531.6ºC at 760 mmHg

[ 熔点 ]:
272-273ºC

[ 分子式 ]:
C₈H₈F₃N₃O₄S₂

[ 分子量 ]:
331.29200

[ 闪点 ]:
275.3ºC

[ 精确质量 ]:
330.99100

[ PSA ]:
135.12000

[ LogP ]:
3.34280

[ 蒸汽压 ]:
2.2E-11mmHg at 25°C

[ 折射率 ]:
1.55

[ 储存条件 ]:
Refrigerator

氢氟噻嗪MSDS

氢氟噻嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK9625000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 135-09-1

BEILSTEIN REFERENCE NO. :: 0342692

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H8-F3-N3-O4-S2

MOLECULAR WEIGHT :: 331.31

WISWESSER LINE NOTATION :: T66 BSWM EM DHJ HXFFF ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,629,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6280 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 134,273,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1182 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #80M

氢氟噻嗪安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H334

[ 警示性声明 ]:
P261-P280-P284-P304 + P340-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DK9625000

[ 海关编码 ]:
2935009090

氢氟噻嗪合成路线

氢氟噻嗪上下游产品

氢氟噻嗪上游产品

氢氟噻嗪下游产品

氢氟噻嗪海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

氢氟噻嗪文献

Do thiazides reduce intestinal oxalate absorption?: a study in vitro using rabbit colon.

Clin. Sci. 86(3) , 353-7, (1994)

1. The purpose of the present study was to examine the effects of various diuretics on intestinal oxalate transport. Transmural oxalate fluxes were measured across isolated, short-circuited tissue seg...

Comparative effects of LN 5330 and diazoxide on insulin release and 86Rb+ permeability in perifused rat islets of Langerhans.

Biochem. Pharmacol. 42(4) , 787-91, (1991)

The benzothiadiazine derivative LN 5330 (chloro-7 trifluoromethyl-6 benzothiadiazine-1,2,4-dioxide-1,1) has been shown to inhibit insulin secretion and calcium uptake. The present study was carried ou...

Metabolic effects of propranolol and hydroflumethiazide treatment in Kenyans with mild to moderate essential hypertension.

East Afr. Med. J. 70(11) , 696-700, (1993)

In a prospective single-blind comparative trial, sixty newly diagnosed mild to moderate hypertensives were randomly assigned to either propranolol or hydroflumethiazide monotherapy. Baseline fasting s...

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