硫酸麻黄碱
硫酸麻黄碱名称
[ CAS 号 ]:
134-72-5
[ 中文名 ]:
硫酸麻黄碱
[ 英文名 ]:
Ephedrine sulfate
[英文别名 ]:
- EINECS 205-154-4
- MFCD00066147
- Ephedrine l-sulfate
- Isofedrol
- Ephedrine sulphate
- UNII-U6X61U5ZEG
- l-Ephedrine sulfate
硫酸麻黄碱物理化学性质
[ 沸点 ]:
255ºC at 760 mmHg
[ 熔点 ]:
248-250ºC
[ 分子式 ]:
C20H32N2O6S
[ 分子量 ]:
428.54300
[ 闪点 ]:
85.6ºC
[ 精确质量 ]:
428.19800
[ PSA ]:
147.50000
[ LogP ]:
3.86560
[ 外观性状 ]:
白色结晶粉末
[ 蒸汽压 ]:
7.48E-16mmHg at 25°C
[ 稳定性 ]:
Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
硫酸麻黄碱MSDS
硫酸麻黄碱毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KB2625000
- CAS REGISTRY NUMBER :
- 134-72-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C20-H30-N2-O2.H2-O4-S
- MOLECULAR WEIGHT :
- 428.60
- WISWESSER LINE NOTATION :
- QYR&Y1&M1 2 WSQQ -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Vascular - BP elevation not characterized in autonomic section
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 404 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 102 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 812 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 270 mg/kg
- TOXIC EFFECTS :
- Behavioral - Straub tail Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 825 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 383 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 73 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 340 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 425 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 530 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - ataxia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18200 mg/kg/13W-C
- TOXIC EFFECTS :
- Cardiac - changes in heart weight Endocrine - changes in adrenal weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8120 mg/kg/14D-C
- TOXIC EFFECTS :
- Blood - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 91 gm/kg/13W-C
- TOXIC EFFECTS :
- Blood - other changes
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - rat Liver
- DOSE/DURATION :
- 3 mmol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84417 No. of Facilities: 2470 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 9457 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84417 No. of Facilities: 233 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 5373 (estimated) No. of Female Employees: 3199 (estimated)
硫酸麻黄碱安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 警示性声明 ]:
P301 + P312 + P330
[ 危害码 (欧洲) ]:
Xn: Harmful;
[ 风险声明 (欧洲) ]:
R22
[ 安全声明 (欧洲) ]:
22-25
[ 危险品运输编码 ]:
UN 1544
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2939410020
硫酸麻黄碱海关
[ 海关编码 ]: 2939410020
推荐生产厂家/供应商：
相关化合物
【硫酸麻黄碱】化源网提供硫酸麻黄碱CAS号134-72-5，硫酸麻黄碱MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询硫酸麻黄碱上化源网，专业又轻松。>>电脑版：硫酸麻黄碱
标题：硫酸麻黄碱_MSDS_熔点_沸点_硫酸麻黄碱CAS号【134-72-5】_化源网 地址：https://www.chemsrc.com/amp/cas/134-72-5_259586.html