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Pancreastatin (33-48) (human) trifluoroacetate salt

用途

胰腺抑制素(37-52),人是胰腺抑制素片段。胰蛋白酶抑制剂是一种具有生物活性的CgA衍生肽(CgA残基250–301),可抑制胰岛β细胞释放胰岛素[1][2]。

名称

[ CAS 号 ]:
133605-57-9

[ 英文名 ]:
Pancreastatin (33-48) (human) trifluoroacetate salt

[英文别名 ]:

Pancreastatin Fragment 37-52 human

生物活性

[ 描述 ]:

胰腺抑制素(37-52),人是胰腺抑制素片段。胰蛋白酶抑制剂是一种具有生物活性的CgA衍生肽(CgA残基250–301),可抑制胰岛β细胞释放胰岛素[1][2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Qiao XW, et al. Chromogranin A is a reliable serum diagnostic biomarker for pancreatic neuroendocrine tumors but not for insulinomas. BMC Endocr Disord. 2014 Aug 7;14:64.

[2]. O'Dorisio TM, et al. Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior. Pancreas. 2010 Jul;39(5):611-6.

物理化学性质

[ 分子式 ]:
C₇₈H₁₂₃N₂₁O₂₇S

[ 分子量 ]:
1819.00000

[ 精确质量 ]:
1817.86000

[ PSA ]:
813.61000

[ LogP ]:
1.76890

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties.

Cell. Mol. Life Sci. 64 , 2863-2886, (2007)

Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The...

Metabolic effects and mechanism of action of the chromogranin A-derived peptide pancreastatin.

Regul. Pept. 161 , 8-14, (2010)

Pancreastatin is one of the regulatory peptides derived from intracellular and/or extracellular processing of chromogranin A, the soluble acidic protein present in the secretory granules of the neuroe...

Effect of chromogranin A (pancreastatin) fragment on invasion of prostate cancer cells.

Cancer Lett. 147 , 207-213, (1999)

We investigated the effect of chromogranin A (pancreastatin) fragment on the invasion of PC-3, DU-145 and LNCaP prostate cancer cells through a reconstituted basement membrane (Matrigel) using a Trans...

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