青霉素B
青霉素B名称
[ CAS 号 ]:
132-93-4
[ 中文名 ]:
苯氧乙基青霉素钾
[ 英文名 ]:
phenethicillin potassium
[中文别名 ]:
[英文别名 ]:
- penova
- brl152
- darcil
- brocsil
- PHENETHICILLIN POTASSIUM SALT
- alpen
- broxil
- EINECS 205-084-4
- maxipen
- potassium phenethicillin
青霉素B物理化学性质
[ 沸点 ]:
673.9ºC at 760 mmHg
[ 分子式 ]:
C17H19KN2O5S
[ 分子量 ]:
402.50600
[ 闪点 ]:
361.3ºC
[ 精确质量 ]:
402.06500
[ PSA ]:
124.07000
[ LogP ]:
0.07970
[ 蒸汽压 ]:
4.44E-19mmHg at 25°C
青霉素B毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH9350000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2- phenoxypropionamido)-, monopotassium salt
- CAS REGISTRY NUMBER :
- 132-93-4
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H19-N2-O5-S.K
- MOLECULAR WEIGHT :
- 402.54
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMVY1&OR& F1 F1 GVQ &-KA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,751,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 85,289,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1896 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,119,1959/1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 312 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,119,1959/1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >103 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 7,119,1959/1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 324 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year: 2,311,1970
青霉素B安全信息
[ WGK德国 ]:
2
[ RTECS号 ]:
XH9700000
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相关化合物
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