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邻苯二甲酸单丁酯

邻苯二甲酸单丁酯用途

Monobutyl phthalate 是邻苯二甲酸二丁酯(DBP)的主要代谢物,具有抗雄激素作用。Monobutyl phthalate是一种胚胎毒物。

邻苯二甲酸单丁酯名称

[ CAS 号 ]:
131-70-4

[ 中文名 ]:
邻苯二甲酸单丁酯

[ 英文名 ]:
Monobutyl Phthalate

[中文别名 ]:

酞酸一丁酯

[英文别名 ]:

Butyl Hydrogen Phthalate
MFCD00043498
EINECS 205-036-2
MONOBUTYL PHTHALATE
mono-Butyl phthalate
Monobutyl phthalate (mBP)
mono-n-butyl ester
Phthalic Acid Monobutyl Ester

邻苯二甲酸单丁酯生物活性

[ 描述 ]:

Monobutyl phthalate 是邻苯二甲酸二丁酯(DBP)的主要代谢物,具有抗雄激素作用。Monobutyl phthalate是一种胚胎毒物。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. van Dartel DA, et al. Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reprod Toxicol. 2009 Apr;27(2):93-102.

[2]. Ema M, et al. Antiandrogenic effects of dibutyl phthalate and its metabolite, monobutyl phthalate, in rats. Congenit Anom (Kyoto). 2002 Dec;42(4):297-308.

邻苯二甲酸单丁酯物理化学性质

[ 密度 ]:
1.173g/cm3

[ 沸点 ]:
363.5ºC at 760mmHg

[ 熔点 ]:
73 °C

[ 分子式 ]:
C₁₂H₁₄O₄

[ 分子量 ]:
222.23700

[ 闪点 ]:
138.2ºC

[ 精确质量 ]:
222.08900

[ PSA ]:
63.60000

[ LogP ]:
2.34170

[ 储存条件 ]:
Refrigerator

邻苯二甲酸单丁酯MSDS

邻苯二甲酸单丁酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI2475000

CHEMICAL NAME :: Phthalic acid, monobutyl ester

CAS REGISTRY NUMBER :: 131-70-4

BEILSTEIN REFERENCE NO. :: 2051402

LAST UPDATED :: 199712

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H14-O4

MOLECULAR WEIGHT :: 222.26

WISWESSER LINE NOTATION :: QVR BVO4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV. Volume(issue)/page/year: 273,2165,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8400 mg/kg/1W-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 14,79,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 40 gm/kg

SEX/DURATION :: female 15-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: JPDSA3 Journal of Pediatric Surgery. (Grune and Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1966- Volume(issue)/page/year: 32,18,1997

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1875 mg/kg

SEX/DURATION :: female 13-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 31,170,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2250 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 31,170,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 78,101,1995

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 3200 mg/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 45,77,1982

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16800 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 6,239,1980

邻苯二甲酸单丁酯安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360

[ 警示性声明 ]:
P201-P308 + P313

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
61-62

[ 安全声明 (欧洲) ]:
53-36/37-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TI2475000

[ 海关编码 ]:
2918990090

邻苯二甲酸单丁酯合成路线

邻苯二甲酸单丁酯海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

邻苯二甲酸单丁酯文献

Feasibility of ultra-high performance liquid and gas chromatography coupled to mass spectrometry for accurate determination of primary and secondary phthalate metabolites in urine samples.

Anal. Chim. Acta 853 , 625-36, (2014)

Phthalates (PAEs) are ubiquitous toxic chemical compounds. During the last few years, some phthalate metabolites (MPAEs) have been proposed as appropriate biomarkers in human urine samples to determin...

Determination and separation of bisphenol A, phthalate metabolites and structural isomers of parabens in human urine with conventional high-pressure liquid chromatography combined with electrospray ionisation tandem mass spectrometry.

Anal. Bioanal. Chem 407(9) , 2509-18, (2015)

Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrom...

A negative correlation between insulin-like peptide 3 and bisphenol A in human cord blood suggests an effect of endocrine disruptors on testicular descent during fetal development.

Hum. Reprod. 30(2) , 447-53, (2015)

Does a relationship exist between insulin-like peptide 3 (INSL3) and selected environmental endocrine disruptors (EEDs) in human cord blood (cb)?In the whole population (cryptorchid and control boys) ...

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