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艾塞那肽

艾塞那肽用途

Exendin-3是从吉拉怪兽蜥蜴 Heloderma horridurn 毒液分离的生物活性肽。

艾塞那肽名称

[ CAS 号 ]:
130357-25-4

[ 中文名 ]:
艾塞那肽

[ 英文名 ]:
Exendin-3 trifluoroacetate salt

[英文别名 ]:

MFCD00240170

艾塞那肽生物活性

[ 描述 ]:

Exendin-3是从吉拉怪兽蜥蜴 Heloderma horridurn 毒液分离的生物活性肽。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

多肽产品

[ 靶点 ]

VIP receptor, putative exendin receptor[1]

[体外研究]

Exendin-3与豚鼠胰腺腺泡中的至少两种受体相互作用;在高浓度(> 100nM)下,肽与VIP受体相互作用,从而引起cAMP的大量增加和刺激淀粉酶释放;在较低浓度(0.1-3nM)下,肽与推定的毒蜥外泌肽受体相互作用,从而导致未确定功能的cAMP的较小增加[1]。

[激酶实验]

用VIP，促胰液素或毒蜥外泌肽-3观察到增加浓度的两种VIP受体拮抗剂对淀粉酶释放增加的影响。将雄性Hartley豚鼠Acini与VIP（1nM），促胰液素（1μM）或Exendin-3（1μM）在37℃温育30分钟，单独或与指定浓度的[AcTyr，D-Phe]组合] GRF 1-29酰胺（实心符号）或[4-Cl-D-Phe，Leu] VIP（空心符号）[1]。

[参考文献]

[1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15;266(5):2897-902.

[相关活性小分子]

艾塞那肽物理化学性质

[ 分子式 ]:
C₁₈₄H₂₈₂N₅₀O₆₁S

[ 分子量 ]:
4202.57

[ 储存条件 ]:
−20°C

艾塞那肽安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

艾塞那肽文献

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

J. Biol. Chem. 267 , 7402, (1992)

The recent identification in Heloderma horridum venom of exendin-3, a new member of the glucagon superfamily that acts as a pancreatic secretagogue, prompted a search for a similar peptide in Heloderm...

Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.

J. Clin. Invest. 101 , 1334-1341, (1998)

To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormone (LHRH) rele...

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

Diabetes 55(12) , 3463-9, (2006)

In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GL...

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