右美沙芬

右美沙芬用途

Dextromethorphan is a dextratrorotatory morphinan, binds to and inhibits NMDA and nicotinic receptor and blocks receptor-gated and voltage-gated calcium channels and voltage-gated sodium channels.

右美沙芬名称

[ CAS 号 ]:
125-71-3

[ 中文名 ]:
右美沙芬

[ 英文名 ]:
Dextromethorphan

[中文别名 ]:

右甲吗喃

[英文别名 ]:

Dexyromethorphan
Vicks 44 Cough Relief
Diabe-Tuss DM Syrup
l-Methorphan
Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
Dextrometorfano [INN-Spanish]
Pertussin CS Children's Strength
Robitussin Pediatric Cough Suppressant
Trocal
Creo-Terpin

右美沙芬物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
394.9±42.0 °C at 760 mmHg

[ 分子式 ]:
C₁₈H₂₅NO

[ 分子量 ]:
271.397

[ 闪点 ]:
116.2±30.2 °C

[ 精确质量 ]:
271.193604

[ PSA ]:
12.47000

[ LogP ]:
4.11

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
?20°C

右美沙芬MSDS

右美沙芬毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD0194000

CHEMICAL NAME :: 9-alpha,13-alpha,14-alpha-Morphinan, 3-methoxy-17-methyl-

CAS REGISTRY NUMBER :: 125-71-3

BEILSTEIN REFERENCE NO. :: 0088549

LAST UPDATED :: 199803

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H25-N-O

MOLECULAR WEIGHT :: 271.44

WISWESSER LINE NOTATION :: T6 G666/FQ 2AF Q FX OM&TTTJ IO1 O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - changes in motor activity (specific assay) Behavioral - ataxia

REFERENCE :: PECAE5 Pediatric Emergency Care. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1985- Volume(issue)/page/year: 7,163,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 116 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,1188,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16286 ug/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 45,1188,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1523,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 7,372,1959 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4165 No. of Facilities: 86 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 3059 (estimated) No. of Female Employees: 1803 (estimated)

右美沙芬安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
16-36/37-45

[ 危险品运输编码 ]:
3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

右美沙芬合成路线

右美沙芬上下游产品

右美沙芬上游产品

右美沙芬下游产品

右美沙芬文献

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Identification of the rat liver cytochrome P450 enzymes involved in the metabolism of the calcium channel blocker dipfluzine hydrochloride.

Environ. Toxicol. Pharmacol. 38(3) , 901-12, (2014)

This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation an...

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