亚磷酸三甲酯

亚磷酸三甲酯用途

亚磷酸三甲酯是一种重要的有机磷中间体，可用于合成有机磷杀虫剂敌敌畏、久效磷、磷胺、速灭磷、百治磷、杀虫畏等，也可合成其他中间体如O，O-二甲基磷酰氯、O，O-二甲基硫(醇)代磷酸盐等，此外，还用于其他有机合成、化纤阻燃、离子薄膜、医药工业等方面。

亚磷酸三甲酯名称

[ CAS 号 ]:
121-45-9

[ 中文名 ]:
三甲氧基磷

[ 英文名 ]:
Trimethyl phosphite

[中文别名 ]:

亚磷酸三甲酯

[英文别名 ]:

Methyl phosphite (P(OMe)3
dimethyl methylphosphonate
Trimethylfosfit
Trimethylphosphite
Methyl phosphite
Trimethyl phosphite
Fosforyn trojmetylowy
MFCD00008350
EINECS 204-471-5
Trimethoxyphosphine

亚磷酸三甲酯物理化学性质

[ 密度 ]:
1.052 g/mL at 25 °C(lit.)

[ 沸点 ]:
110.2±8.0 °C at 760 mmHg

[ 熔点 ]:
−78 °C(lit.)

[ 分子式 ]:
C₃H₉O₃P

[ 分子量 ]:
124.076

[ 闪点 ]:
27.8±0.0 °C

[ 精确质量 ]:
124.028931

[ PSA ]:
41.28000

[ LogP ]:
-0.93

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
4.3 (vs air)

[ 蒸汽压 ]:
28.1±0.2 mmHg at 25°C

[ 折射率 ]:
n20/D 1.408(lit.)

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放,防潮

亚磷酸三甲酯MSDS

亚磷酸三甲酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH1400000

CHEMICAL NAME :: Phosphorous acid, trimethyl ester

CAS REGISTRY NUMBER :: 121-45-9

LAST UPDATED :: 199712

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C3-H9-O3-P

MOLECULAR WEIGHT :: 124.09

WISWESSER LINE NOTATION :: 1OPO1&O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,609,1969

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - species unspecified

REFERENCE :: MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Mammal - species unspecified

REFERENCE :: MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 29,393,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ALBRW* Albright & Wilson Inc. (P.O. Box 26229, Richmond, VA 23260-6229) Volume(issue)/page/year: #OPB-3,1984

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 9,1,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/7.5H/8W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Skin and Appendages - hair

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 34,286,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1640 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 72,119,1984 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.5 ppm (2.6 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.5 ppm (2.6 mg/m3);STEL 10 ppm (52 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO TRIMETHYL PHOSPHITE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84215 No. of Facilities: 260 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 1891 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84215 No. of Facilities: 55 (estimated) No. of Industries: 2 No. of Occupations: 18 No. of Employees: 14190 (estimated) No. of Female Employees: 6312 (estimated)

亚磷酸三甲酯安全信息

[ 符号 ]:

GHS02, GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H302-H315-H318-H335

[ 补充危害声明 ]:
Reacts violently with water.

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
UN 2329 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
TH1400000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

[ 海关编码 ]:
2920901100

亚磷酸三甲酯合成路线

亚磷酸三甲酯上下游产品

亚磷酸三甲酯上游产品

亚磷酸三甲酯下游产品

亚磷酸三甲酯制备

1.酯交换法先将苯酚与三氯化磷反应，生成亚磷酸三苯酯，然后在甲醇钠存在下与甲醇进行酯交换生成亚磷酸三甲酯。粗酯经蒸馏脱除残余甲醇及苯酚，成为成品。

原料消耗定额：苯酚（凝固点≥40℃）237kg/t；三氯化磷（96%）1396kg/t；甲醇（98%）855kg/t；甲醇钠（27-31%）83kg/t。

2.叔胺-氨法是以二甲苯为溶剂，甲醇和三氯化磷在N，N-二甲基苯胺存在下进行酯化反应，生成亚磷酸三甲酯。再经水洗；脱水；精馏得成品。

原料消耗定额：甲醇（95%）1025kg/t；三氯化磷1430kg/t；二甲苯130kg/t；二甲基苯胺51kg/t

3.在装有回流冷凝器、滴液漏斗和温度计的三颈烧瓶中，放入0.3摩尔甲醇、0.3摩尔胺和100毫升乙醚。在稳定搅拌和保持7一10的温度下，从滴液漏斗中慢慢加入0.1摩尔三氯化磷溶于50毫升乙醚的溶液。反应在1一1.5小时内完成。滤去沉淀出来的胺盐酸盐。将滤液蒸去乙醚，再蒸馏剩余物即得亚磷酸三甲酯。

亚磷酸三甲酯海关

[ 海关编码 ]: 2920901100

[ 中文概述 ]:
2920901100 亚磷酸三甲酯。监管条件:23(两用物项和技术进口许可证,两用物项和技术出口许可证)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: 2.两用物项和技术进口许可证 3.两用物项和技术出口许可证

[ Summary ]:
2920901100 trimethyl phosphite。supervision conditions:23(import license for dual-use item and technologies,export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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