三乙胺

三乙胺用途

1、用于制造医药、农药、阻聚剂、高能燃料、橡胶硫化剂等
2、用于第四胺类化合物的制备及催化剂的合成，也用作溶剂、橡胶硫化促进剂、渗透剂和防水剂
3、在有机合成工业中可用作溶剂、催化剂及原料。可用来制取光气法聚碳酸酯的催化剂、四氟乙烯的阻聚剂、橡胶硫化促进剂，脱漆剂中的特殊溶剂、搪瓷抗硬化剂、表面活性剂、防腐剂、杀菌剂、离子交换树脂、染料、香料、药物、高能燃料和液体火箭推进剂等。医药工业中消耗三乙胺的产品有（消耗定额，t/t）：氨苄青霉素钠（0.465），羟氨苄青霉素（0.391），先锋Ⅳ（2.550），头孢唑啉钠（2.442），头孢拉啶（1.093），氧哌嗪青霉素（0.584），酮康唑（8.00），维生素B6（0.502），氟啶酸（10.00），吡喹酮（0.667），噻替哌（1.970），青霉胺（1.290），盐酸黄连素（0.030），异搏定（0.540），阿普唑仑（3.950），邻氯苯乙酸（0.010）以及吡哌酸等。
4、制造季铵化合物, 合成催化剂, 橡胶硫化促进剂, 照相工业, 溶剂。在RP-HPLC分离酸性、中性和碱性药物中作为流动相修饰剂.

三乙胺名称

[ CAS 号 ]:
121-44-8

[ 中文名 ]:
三乙胺

[ 英文名 ]:
Triethylamine

[中文别名 ]:

[英文别名 ]:

N,N-diethylethanamine
EINECS 204-469-4
MFCD00009051

三乙胺物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
90.5±8.0 °C at 760 mmHg

[ 熔点 ]:
-115 °C

[ 分子式 ]:
C₆H₁₅N

[ 分子量 ]:
101.190

[ 闪点 ]:
-6.7±0.0 °C

[ 精确质量 ]:
101.120445

[ PSA ]:
3.24000

[ LogP ]:
1.66

[ 外观性状 ]:
无色液体

[ 蒸汽密度 ]:
3.5 (vs air)

[ 蒸汽压 ]:
56.1±0.2 mmHg at 25°C

[ 折射率 ]:
1.412

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、酸类分开存放

[ 稳定性 ]:
Stable. Extremely flammable. Readily forms explosive mixtures with air. Note low flash point. Incompatible with strong oxidizing agents, strong acids, ketones, aldehydes, halogenated hydrocarbons.

[ 水溶解性 ]:
133 g/L (20 ºC)

三乙胺MSDS

详细MSDS(安全技术说明书)

三乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YE0175000

CHEMICAL NAME :: Triethylamine

CAS REGISTRY NUMBER :: 121-44-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 45

MOLECULAR FORMULA :: C6-H15-N

MOLECULAR WEIGHT :: 101.22

WISWESSER LINE NOTATION :: 2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 12 mg/m3/11W-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 546 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 gm/m3

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 405 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 570 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 6 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4223 mg/kg/11W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/m3/3H/26W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Blood - changes in platelet count Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 mg/m3

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 36(11),9,1971 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 12 mg/m3 (3 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 4.1 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (100 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,268,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3);STEL 15 ppm (60 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (41 mg/m3);STEL 15 ppm (62 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 mg/m3;STEL 20 mg/m3;Skin JAN 1993 OEL-FRANCE:STEL 10 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (100 mg/m3) JAN 1993 OEL-RUSSIA:STEL 10 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 2 ppm (8 mg/m3);STEL 10 ppm (40 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);STEL 20 ppm (80 mg/m3) JAN 1993 OEL-TURKEY:TWA 25 ppm (100 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (40 mg/m3);STEL 15 ppm (60 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 74175 No. of Facilities: 959 (estimated) No. of Industries: 15 No. of Occupations: 21 No. of Employees: 10558 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6415 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 622 (estimated) No. of Female Employees: 55 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 74175 No. of Facilities: 3153 (estimated) No. of Industries: 74 No. of Occupations: 52 No. of Employees: 68091 (estimated) No. of Female Employees: 9701 (estimated)

三乙胺安全信息

[ 符号 ]:

GHS02, GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H311 + H331-H314-H335

[ 警示性声明 ]:
P210-P261-P280-P303 + P361 + P353-P305 + P351 + P338-P370 + P378

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive

[ 风险声明 (欧洲) ]:
R11;R20/21/22;R35

[ 安全声明 (欧洲) ]:
S3-S16-S26-S29-S36/37/39-S45

[ 危险品运输编码 ]:
UN 1296 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
YE0175000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
2921199011

三乙胺合成路线

详细合成路线

三乙胺上下游产品

三乙胺上游产品

三乙胺下游产品

三乙胺制备

1.可用乙醇和氨作用制得。将乙醇和液氨在氢气存在下，经气化后进入预热器（150±5℃）进行预热，然后进入装有铜-镍-白土催化剂的第一反应器（190±2℃）和第二反应器（165±2℃）进行合成，生成一乙胺；二乙胺；三乙胺的混合物，经冷凝后，再经乙醇喷淋吸收得三乙醇胺粗品，最后经分离；脱水和分馏，收集88-90℃馏分得三乙胺。原料消耗定额：乙醇（95%）2300kg、t；液氨（99%）500kg、t；氢气（99%）150标立方米、t。

精制方法：常含有乙胺、二乙胺和乙醛等杂质，一般用分馏的方法精制。为了除去微量的伯胺和仲胺，可加入乙酸酐、苯甲酸酐或邻苯二甲酸酐回流后分馏，馏出物用活性氧化铝或固体氢氧化钾干燥后再蒸馏。其他精制方法有：将三乙胺转变成盐酸盐，再用乙醇重结晶，至熔点达到254℃时，与氢氧化钠水溶液作用，以游离出三乙胺，经固体氢氧化钾干燥后，在钠存在下于氮气流中蒸馏得纯品。

2.在氧气存在下，乙醇与氨在铜、镍、白土催化剂存在下加热进行合成反应，生成一、二、三乙胺混合物。混合物经冷凝、萃取、吸收制得粗品。粗品再经分离、静置分层、脱水、蒸馏即得产品。

3.将乙醇（kg）、液氨（kg）、氢气（标m³）按23∶50∶15的比例混合后预热至145～155℃，通入装有铜镍白土催化剂的第一反应器（190℃左右）和第二反应器（165℃左右）反应，生成一乙胺、二乙胺和三乙胺的混合物，经冷凝后进行精馏，收集88～90℃馏分即三乙胺。反应式如下：

4.合成：由氯乙烷与氨在压力下加热而得。

三乙胺海关

[ 海关编码 ]: 2921199011

[ 中文概述 ]:
2921199011 三乙胺〔单一成分,用做点火剂〕。监管条件:3(两用物项和技术出口许可证)A(两用物项和技术出口许可证,入境货物通关单)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: 3.两用物项和技术出口许可证 A.入境货物通关单

[ 检验检疫 ]: M.进口商品检验

[ Summary ]:
2921199011 triethylamine。supervision conditions:3(export license for dual-use item and technologies)a(export license for dual-use item and technologies,certificate of inspection for goods inward)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

三乙胺文献

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The drug delivery platform for folic acid (FA)-coated nanoformulated ritonavir (RTV)-boosted atazanavir (FA-nanoATV/r) using poloxamer 407 was developed to enhance cell and tissue targeting for a rang...

TiO2 immobilized on Manihot carbon: optimal preparation and evaluation of its activity in the decomposition of indigo carmine.

Int. J. Mol. Sci. 16(1) , 1590-612, (2015)

Applications of carbon-TiO2 materials have attracted attention in nanotechnology due to their synergic effects. We report the immobilization of TiO2 on carbon prepared from residues of the plant Manih...

Biocompatible, biodegradable and porous liquid crystal elastomer scaffolds for spatial cell cultures.

Macromol. Biosci. 15(2) , 200-14, (2015)

Here we report on the modular synthesis and characterization of biodegradable, controlled porous, liquid crystal elastomers (LCE) and their use as three-dimensional cell culture scaffolds. The elastom...

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三乙胺