苯醚甲环唑

苯醚甲环唑用途

苯醚甲环唑是一种广谱的三唑类杀菌剂,它通过抑制细胞色素P450依赖的14α-去甲基化作用抑制麦角甾醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。苯醚甲环唑对禾谷镰刀菌的体外生长有抑制作用(菌丝生长的EC50s=1.69-19.6mg/L)。苯醚甲环唑还可抑制索纳利、富尔瓦、灰葡萄球菌和索拉尼葡萄球菌的生长(EC50s分别为0.131 mg/L、0.069 mg/L、0.297 mg/L和0.252 mg/L)。

苯醚甲环唑名称

[ CAS 号 ]:
119446-68-3

[ 中文名 ]:
苯醚甲环唑

[ 英文名 ]:
difenoconazole

[中文别名 ]:

[英文别名 ]:

Diflubenzuron
3-chloro-4-[(2RS,4RS
T5O COTJ BR BG DOR DG&& D1 B1- AT5NN DNJ
Difenoconazol
MFCD00144119
difenoconazole

苯醚甲环唑生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

苯醚甲环唑物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
547.0±60.0 °C at 760 mmHg

[ 熔点 ]:
76°C

[ 分子式 ]:
C₁₉H₁₇Cl₂N₃O₃

[ 分子量 ]:
406.263

[ 闪点 ]:
284.6±32.9 °C

[ 精确质量 ]:
405.064697

[ PSA ]:
58.40000

[ LogP ]:
4.92

[ 外观性状 ]:
无色固体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.642

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
3.3 mg/L (20 ºC)

苯醚甲环唑MSDS

详细MSDS(安全技术说明书)

苯醚甲环唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ4380000

CHEMICAL NAME :: 1H-1,2,4-Triazole, 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1 ,3-dioxolan-2- yl)methyl)-

CAS REGISTRY NUMBER :: 119446-68-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H17-Cl2-N3-O3

MOLECULAR WEIGHT :: 406.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1453 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >45 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2010 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,277,1991

苯醚甲环唑安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H332-H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R41;R43

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
XZ4380000

苯醚甲环唑文献

Comparison of greenhouse and field degradation behaviour of isoprocarb, hexaflumuron and difenoconazole in Perilla frutescens.

Bull. Environ. Contam. Toxicol. 89(4) , 868-72, (2012)

Isoprocarb, hexaflumuron and difenoconazole were used in Perilla frutescens at 600, 60 and 75 g a.i./ha respectively. High performance liquid chromatography-tandem mass spectrometry was used for resid...

[Behaviour azole fungicide and fluconazole in Cryptococcus neoformans clinical and environmental isolates].

Rev. Soc. Bras. Med. Trop. 40(2) , 209-11, (2007)

The activity of azole fungicides for agronomical use (epoxiconazole, difenoconazole and cyproconazole) was evaluated in comparison with the therapeutic antifungal agent fluconazole, on 23 environmenta...

Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.

PLoS ONE 7(3) , e31801, (2012)

Azoles play an important role in the management of Aspergillus diseases. Azole resistance is an emerging global problem in Aspergillus fumigatus, and may develop through patient therapy. In addition, ...

更多文献