2-Methylcitric acid trisodium

2-Methylcitric acid trisodium用途

2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid trisodium 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid trisodium 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。

2-Methylcitric acid trisodium名称

[ CAS 号 ]:
117041-96-0

[ 英文名 ]:
2-Methylcitric acid trisodium

2-Methylcitric acid trisodium生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

2-甲基柠檬酸三钠损害谷氨酸代谢,诱导脑线粒体通透性转变[1]。2-甲基柠檬酸三钠在浓度低至0.5mm时抑制谷氨酸脱氢酶(GDH)活性[1]。2-甲基柠檬酸三钠(1 mM,3 mM；150秒)引起线粒体膜电位显著降低,并诱导不同底物支持的钙离子负载线粒体肿胀[1]。2-甲基柠檬酸三钠通过抑制谷氨酸脱氢酶活性和作为通透性转变诱导剂,干扰线粒体能量平衡(1),作为谷氨酸氧化的强有力抑制剂。2-甲基柠檬酸三钠不明显损害线粒体谷氨酸转运[1]。2-甲基柠檬酸三钠对肝线粒体谷氨酸线粒体转运无明显损害[1]。

[参考文献]

[1]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10.

2-Methylcitric acid trisodium物理化学性质

[ 分子式 ]:
C₇H₇Na₃O₇

[ 分子量 ]:
272.10

2-Methylcitric acid trisodium安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

2-Methylcitric acid trisodium文献

The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism.

Nat. Commun. 5 , 4993, (2014)

A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occurs during...

Effect of 2-methylcitrate on citrate metabolism: implications for the management of patients with propionic acidemia and methylmalonic aciduria.

Pediatr. Res. 9 , 905-8, (1975)

2-Methylcitrate was tested in vitro on enzymes which interact with citrate and isocitrate. It was found to inhibit citrate synthase, aconitase, the NAD+- and NADP+-linked isocitrate dehydrogenase. Thi...

Propionyl coenzyme A is a common intermediate in the 1,2-propanediol and propionate catabolic pathways needed for expression of the prpBCDE operon during growth of Salmonella enterica on 1,2-propanediol.

J. Bacteriol. 185 , 2802-2810, (2003)

The studies reported here identify propionyl coenzyme A (propionyl-CoA) as the common intermediate in the 1,2-propanediol and propionate catabolic pathways of Salmonella enterica serovar Typhimurium L...

更多文献