黄曲霉毒素G1

黄曲霉毒素G1用途

Aflatoxin G1 是一种自然界中产生的黄曲霉毒素,它是由 Aspergillus flavus 和 Aspergillus parasiticus 等霉菌产生的。 Aflatoxins 是饲料,坚果,葡萄酒,香料和其他粮食作物中发现的致肝,致畸,致癌的真菌代谢物。

黄曲霉毒素G1名称

[ CAS 号 ]:
1165-39-5

[ 中文名 ]:
黄曲霉素 G1

[ 英文名 ]:
Aflatoxin G1

[中文别名 ]:

[英文别名 ]:

AF G1
MFCD00005089
Aflatoxin G(1)
aflatoxin g1 solution
AFLATOXIN G
EINECS 214-615-9
Aflatoxin G1,crystalline
(7ar-cis)-10a-tetrahydro-5-methoxy
10a-tetrahydro-5-methoxy
Aflatoxin G1

黄曲霉毒素G1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sarma UP, et al. Aflatoxins: Implications on Health. Indian J Clin Biochem. 2017 Jun;32(2):124-133.

[2]. Karaaslan M, et al. Aflatoxins B1, B2, G1, and G2 contamination in ground red peppers commercialized in Sanliurfa, Turkey. Environ Monit Assess. 2015 Apr;187(4):184.

黄曲霉毒素G1物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
612.1±55.0 °C at 760 mmHg

[ 熔点 ]:
244-246ºC

[ 分子式 ]:
C₁₇H₁₂O₇

[ 分子量 ]:
328.273

[ 闪点 ]:
274.1±31.5 °C

[ 精确质量 ]:
328.058289

[ PSA ]:
84.20000

[ LogP ]:
-0.17

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.680

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开存放

黄曲霉毒素G1MSDS

黄曲霉毒素G1毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1720000

CAS REGISTRY NUMBER :: 1165-39-5

BEILSTEIN REFERENCE NO. :: 1299768

LAST UPDATED :: 199806

DATA ITEMS CITED :: 39

MOLECULAR FORMULA :: C17-H12-O7

MOLECULAR WEIGHT :: 328.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14900 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pleural effusion Liver - jaundice, other or unclassified Endocrine - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 785 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4100 ug/kg/22W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 mg/kg/30W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5600 ug/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Primate - monkey Kidney

DOSE/DURATION :: 2 mg/L

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 48,1647,1972 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 10,51,1976 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,245,1993 TOXICOLOGY REVIEW LLOYA2 Lloydia. (Cincinnati, OH) V.1-41, 1938-78. For publisher information, see JNPRDF. Volume(issue)/page/year: 38,21,1975 TOXICOLOGY REVIEW BAREA8 Bacteriological Reviews. (Washington, DC) V.1-41, 1937-77. Volume(issue)/page/year: 30,460,1966 TOXICOLOGY REVIEW PMDCAY Progress in Medical Chemistry. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1961- Volume(issue)/page/year: 10,85,1974 TOXICOLOGY REVIEW IJNDAN Indian Journal of Nutrition and Dietetics. (Sri Avinashilingam Home Science College for Women, Coimbatore 641 043, India) V.7- 1970- Volume(issue)/page/year: 8,85,1971

黄曲霉毒素G1安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H304-H315-H319-H340-H350-H372

[ 警示性声明 ]:
P201-P210-P301 + P310-P305 + P351 + P338-P308 + P313-P331

[ 个人防护装备 ]:
Eyeshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;T+: Very toxic;F: Flammable;Xn: Harmful;

[ 风险声明 (欧洲) ]:
R45

[ 安全声明 (欧洲) ]:
53-28-36/37-45-62-26-16-7-36

[ 危险品运输编码 ]:
UN 3462 6

[ WGK德国 ]:
3

[ RTECS号 ]:
LV1720000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

黄曲霉毒素G1合成路线

黄曲霉毒素G1文献

Development and validation of an UHPLC-MS/MS method for the determination of mycotoxins in grass silages.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 2101-12, (2015)

An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) multi-mycotoxin analytical method was developed to simultaneously identify and quantify 20 mycotoxins in grass si...

A multi-analyte LC-MS/MS method for the analysis of 23 mycotoxins in different sorghum varieties: the forgotten sample matrix.

Food Chem. 177 , 397-404, (2015)

An LC-MS/MS method was developed and validated for the detection and quantification of 23 mycotoxins in different varieties of sorghum. The method performance characteristics were as follows: suitable...

Stability of aflatoxins in solution.

J. AOAC Int. 95(4) , 1084-8, (2012)

The stability of aflatoxins B1, B2, G1, and G2 was studied in solutions containing different concentrations of water, acetonitrile, and/or methanol, and in autosampler vials treated with nitric acid o...

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