黄曲霉素 B1

黄曲霉素 B1用途

Aflatoxin B1 (AFB1) 是一类 1A 级致癌物质,是 Aspergillus flavus 和 A. parasiticus 的次生代谢产物。Aflatoxin B1 (AFB1) 主要通过诱导抑癌基因 p53 中 codon 249 第三位点的 G-->T,从而引起突变。

黄曲霉素 B1名称

[ CAS 号 ]:
1162-65-8

[ 中文名 ]:
黄曲霉素 B1

[ 英文名 ]:
AFLATOXIN B1

[中文别名 ]:

[英文别名 ]:

Aflatoxin B1
Aflatoxin B1 Crystalline
(-)-Aflatoxin B1
Aflatoxin B1, crystalline
MFCD00869647
Aflatoxin
EINECS 214-603-3

黄曲霉素 B1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Gizachew D, et al. Aflatoxin B1 (AFB1) production by Aspergillus flavus and Aspergillus parasiticus on ground Nyjer seeds: The effect of water activity and temperature. Int J Food Microbiol. 2019 May 2;296:8-13.

[2]. Aguilar F, et al. Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8586-90.

黄曲霉素 B1物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
528.2±50.0 °C at 760 mmHg

[ 熔点 ]:
268-269 °C

[ 分子式 ]:
C₁₇H₁₂O₆

[ 分子量 ]:
312.274

[ 闪点 ]:
237.7±30.2 °C

[ 精确质量 ]:
312.063385

[ PSA ]:
74.97000

[ LogP ]:
0.45

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.687

[ 储存条件 ]:
2~8℃，干燥，密封

黄曲霉素 B1MSDS

黄曲霉素 B1安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H350

[ 警示性声明 ]:
P201-P260-P264-P280-P284-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+,T,Xn,F

[ 风险声明 (欧洲) ]:
45-46-26/27/28-36-20/21/22-11-65-48/23/24/25-36/38-39/23/24/25-23/24/25

[ 安全声明 (欧洲) ]:
53-45-36-26-16-24-7

[ 危险品运输编码 ]:
UN 3462 6.1/PG 1

[ WGK德国 ]:
3

[ RTECS号 ]:
GY1925000

[ 包装等级 ]:
I

黄曲霉素 B1合成路线

黄曲霉素 B1文献

Low toxicity of deoxynivalenol-3-glucoside in microbial cells.

Toxins (Basel.) 7(1) , 187-200, (2015)

Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synt...

Aflatoxins contamination in Pakistani brown rice: a comparison of TLC, HPLC, LC-MS/MS and ELISA techniques.

Toxicol. Mech. Methods 24(8) , 544-51, (2014)

Advancement in the field of analytical food-chemistry has explored various experimental techniques for aflatoxins (AFs) quantification. The present study was aimed to compare four different techniques...

Deoxynivalenol-mimic nanobody isolated from a naïve phage display nanobody library and its application in immunoassay.

Anal. Chim. Acta 887 , 201-8, (2015)

In this study, using mycotoxin deoxynivalenol (DON) as a model hapten, we developed a nanobody-based environmental friendly immunoassay for sensitive detection of DON. Two nanobodies (N-28 and N-31) w...

更多文献

黄曲霉素 B1

黄曲霉素 B1用途

黄曲霉素 B1名称

黄曲霉素 B1生物活性

黄曲霉素 B1物理化学性质

黄曲霉素 B1MSDS

详细MSDS(安全技术说明书)

黄曲霉素 B1安全信息

黄曲霉素 B1合成路线

详细合成路线

黄曲霉素 B1文献

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