N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺用途

VU 0361737是一种选择性mGlu4受体正变构调节剂 (PAM), 作用于人类和大鼠受体, EC50分别为240 nM和110 nM, 对mGlu5和mGlu8受体具有微弱的作用活性, 对 mGlu1, mGlu2, mGlu3, mGlu6, 和mGlu7受体没有抑制活性。

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺名称

[ CAS 号 ]:
1161205-04-4

[ 中文名 ]:
N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺

[ 英文名 ]:
VU 0361737

[英文别名 ]:

N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
N-(4-Chloro-3-methoxyphenyl)pyridine-2-carboxamide
ML128
VU 0361737
VU0361737

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Jantas D, et al. Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. Neuropharmacology. 2014 Aug;83:36-53

[2]. Jantas D, et al. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. Neurochem Int. 2015 Sep;88:124

[3]. Engers DW, et al. Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs). J Med Chem. 2009 Jul 23;52(14):4115-8.

[4]. Engers DW, et al. Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats. J Med Ch

[相关活性小分子]

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
329.8±37.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₁ClN₂O₂

[ 分子量 ]:
262.692

[ 闪点 ]:
153.3±26.5 °C

[ 精确质量 ]:
262.050903

[ PSA ]:
54.71000

[ LogP ]:
2.44

[ 外观性状 ]:
white

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.633

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
DMSO: soluble15mg/mL (clear solution)

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺MSDS

详细MSDS(安全技术说明书)

N-(4-氯-3-甲氧基苯基)-2-吡啶甲酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36

[ 安全声明 (欧洲) ]:
26

[ 危险品运输编码 ]:
NONH for all modes of transport