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妥拉磺脲

妥拉磺脲用途

Tolazamide是口服降血糖药，用于治疗2型糖尿病。

妥拉磺脲名称

[ CAS 号 ]:
1156-19-0

[ 中文名 ]:
甲磺氮草脲

[ 英文名 ]:
Tolazamide

[中文别名 ]:

妥拉磺脲

[英文别名 ]:

1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
Tolazamide
EINECS 214-588-3
MFCD00083504

妥拉磺脲生物活性

[ 描述 ]:

Tolazamide是口服降血糖药,用于治疗2型糖尿病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 内分泌

[相关活性小分子]

妥拉磺脲物理化学性质

[ 密度 ]:
1.29g/cm3

[ 沸点 ]:
289 °C772 mm Hg(lit.)

[ 熔点 ]:
171-173 °C(lit.)

[ 分子式 ]:
C₁₄H₂₁N₃O₃S

[ 分子量 ]:
311.40000

[ 闪点 ]:
100 °C

[ 精确质量 ]:
311.13000

[ PSA ]:
86.89000

[ LogP ]:
3.57440

[ 折射率 ]:
1.596

[ 储存条件 ]:
Refrigerator

妥拉磺脲MSDS

详细MSDS(安全技术说明书)

妥拉磺脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT4400000

CHEMICAL NAME :: Urea, 1-(hexahydro-1H-azepin-1-yl)-3-(p-tolylsulfonyl)-

CAS REGISTRY NUMBER :: 1156-19-0

BEILSTEIN REFERENCE NO. :: 1323565

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H21-N3-O3-S

MOLECULAR WEIGHT :: 311.44

WISWESSER LINE NOTATION :: T7NTJ AMVMSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 256 mg/kg/3W-I

TOXIC EFFECTS :: Liver - jaundice, other or unclassified Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 4 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996

妥拉磺脲安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YT4400000

[ 海关编码 ]:
2935009090

妥拉磺脲海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%