N-亚硝基假木贼碱(NAB)

N-亚硝基假木贼碱(NAB)名称

[ CAS 号 ]:
1133-64-8

[ 中文名 ]:
N-亚硝基假木贼碱(NAB)

[ 英文名 ]:
(r,s)-n-nitrosoanabasine

[中文别名 ]:

N-亚硝基哌嗪并吡啶

[英文别名 ]:

n-nitrosoanabasine
3-(1-nitroso-2-piperidyl)pyridine
1-nitrosoanabasine
(s)-3-(1-nitroso-2-piperidinyl)pyridine
MFCD01081833
3-(1-nitrosopiperidin-2-yl)pyridine
1-nitroso-anabasin
3-[(2S)-1-Nitroso-2-piperidinyl]pyridine
(S)-N-Nitroso Anabasine

N-亚硝基假木贼碱(NAB)物理化学性质

[ 密度 ]:
1.24g/cm3

[ 沸点 ]:
380.2ºC at 760mmHg

[ 分子式 ]:
C₁₀H₁₃N₃O

[ 分子量 ]:
191.23000

[ 闪点 ]:
9℃

[ 精确质量 ]:
191.10600

[ PSA ]:
45.56000

[ LogP ]:
2.22790

[ 蒸汽压 ]:
1.21E-05mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
?20°C

N-亚硝基假木贼碱(NAB)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV4550000

CHEMICAL NAME :: Anabasine, 1-nitroso-

CAS REGISTRY NUMBER :: 1133-64-8

LAST UPDATED :: 199506

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H13-N3-O

MOLECULAR WEIGHT :: 191.26

WISWESSER LINE NOTATION :: T6NTJ ANO B- CT6NJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6000 mg/kg/50W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 18,265,1964

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1030 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 71,25,1993

N-亚硝基假木贼碱(NAB)安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 危害码 (欧洲) ]:
F,T

[ 风险声明 (欧洲) ]:
11-23/24/25-39/23/24/25

[ 安全声明 (欧洲) ]:
7-16-36/37-45

[ 危险品运输编码 ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ 海关编码 ]:
2933990090

N-亚硝基假木贼碱(NAB)合成路线

详细合成路线

N-亚硝基假木贼碱(NAB)上下游产品

N-亚硝基假木贼碱(NAB)上游产品

N-亚硝基假木贼碱(NAB)下游产品

N-亚硝基假木贼碱(NAB)海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-亚硝基假木贼碱(NAB)文献

Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: a comparative study.

J. Oral. Pathol. Med. 23(4) , 161-7, (1994)

The purpose of this study was to investigate the uptake and metabolism of nicotine by smokeless (oral) tobacco users and to find out if the less pronounced clinical changes in the oral mucosa in users...

N'-Nitrosoanabasine (NAB).

IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 37 , 225-31, (1985)

Immunotoxic effects of smokeless tobacco on the accessory cell function of rat oral epithelium.

Eur. J. Oral Sci. 105(1) , 45-51, (1997)

Smokeless tobacco (ST) is known to adversely effect the oral mucosa, but knowledge about the influence on immune defence is limited. Few studies have investigated the effect of ST on the local immune ...

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