<生产厂家价格>

(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochromeno[4,3-b][1,4]oxazin-9-olhydrochloride

用途

PD 128907(盐酸)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

名称

[ CAS 号 ]:
112960-16-4

[ 中文名 ]:
反式-3,4,4a,10b-四氢-4-丙基-2H,5H-[1]苯并吡喃并[4,3-b]-1,4-恶嗪-9-醇盐酸盐

[ 英文名 ]:
PD128907 HCl

[英文别名 ]:

S(+)-PD 128,907 hydrochloride
PD 125,530
R(-)-PD 128,908 hydrochloride
(+)-PD 128,907 hydrochloride

生物活性

[ 描述 ]:

PD 128907(盐酸)是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

PD128907盐酸是一种有效的选择性多巴胺第3页受体激动剂,欧洲50为 0.64nM比多巴胺 D2受体选择性高 53倍。

物理化学性质

[ 熔点 ]:
145-153°C

[ 分子式 ]:
C₁₄H₂₀ClNO₃

[ 分子量 ]:
285.77

[ 精确质量 ]:
285.11300

[ PSA ]:
41.93000

[ LogP ]:
2.67640

[ 外观性状 ]:
white

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: >5mg/mL

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

文献

Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.

J. Pharmacol. Exp. Ther. 275 , 1355, (1995)

The present study determined the biochemical and pharmacological effects of PD 128907 [R-(+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol], a dopamine (DA) recepto...

Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.

J. Med. Chem. 33 , 445-450, (1990)

The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate af...

Dopamine D3 (auto) receptors inhibit dopamine release in the frontal cortex of freely moving rats in vivo.

J. Neurochem. 66 , 2209, (1996)

In freely moving rats, the novel, selective dopamine (DA) D3 receptor agonist PD 128,907 dose-dependently [effective dose (ED25) = 0.07 mg/kg, s.c.] reduced dialysate levels of DA in the frontal corte...

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