bleomycin a2
bleomycin a2名称
[ CAS 号 ]:
11116-31-7
[ 英文名 ]:
bleomycin a2
[英文别名 ]:
- Pingyangmycin A2
- Einecs 234-356-5
- Bleogin
- BLEMOYCIN AZ
- Zhengguangmycin A2
- Unii-13m89uea7w
bleomycin a2物理化学性质
[ 分子式 ]:
C55H84N17O21S3+
[ 分子量 ]:
1415.55000
[ 精确质量 ]:
1414.52000
[ PSA ]:
708.85000
[ 储存条件 ]:
库房通风低温干燥
bleomycin a2毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EC5988500
- CHEMICAL NAME :
- Bleomycin A2
- CAS REGISTRY NUMBER :
- 11116-31-7
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 23
- MOLECULAR FORMULA :
- C55-H84-N17-O21-S3
- MOLECULAR WEIGHT :
- 1415.74
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2143 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - fibrosing alveolitis
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 108 mg/kg/36D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg/45D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 221,152,1982
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相关化合物
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