菲律宾菌素复合体

菲律宾菌素复合体用途

Filipin 在自然界中被称为 Filipin complex (Filipins I-IV),Filipin 是一种28-元环五烯大环内酯类抗真菌抗生素,由 S. filipinensis,S. avermitilis 和 S. miharaensis 产生。Filipin 可以与膜甾醇相互作用导致膜结构的改变。Filipin III 是 Filipin 的主要成分。

菲律宾菌素复合体名称

[ CAS 号 ]:
11078-21-0

[ 中文名 ]:
非律平

[ 英文名 ]:
Filipin complex

[英文别名 ]:

菲律宾菌素复合体生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 抗感染 >> 真菌

[参考文献]

[1]. Kelly PM, et al. Separation of the filipin complex by gradient-elution high performance liquid chromatography. J Antibiot (Tokyo). 1985 Apr;38(4):485-9.

[2]. Payero TD, et al. Functional analysis of filipin tailoring genes from Streptomyces filipinensis reveals alternative routes in filipin III biosynthesis and yields bioactive derivatives. Microb Cell Fact. 2015 Aug 7;14:114.

菲律宾菌素复合体物理化学性质

[ 密度 ]:
1.161 g/cm3

[ 沸点 ]:
913.9ºC at 760 mmHg

[ 分子式 ]:
C₃₅H₅₈O₁₁(forFilipinIII)

[ 分子量 ]:
654.82800

[ 闪点 ]:
279.3ºC

[ 精确质量 ]:
654.39800

[ PSA ]:
208.37000

[ LogP ]:
1.88800

[ 外观性状 ]:
淡黄色至黄褐色的粉末

[ 储存条件 ]:
-20°C

菲律宾菌素复合体毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK4400000

CHEMICAL NAME :: Filipin

CAS REGISTRY NUMBER :: 11078-21-0

LAST UPDATED :: 198211

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 2,215,1980

菲律宾菌素复合体安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

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