乙嘧替氟

乙嘧替氟用途

Emitefur 是一种有口服活性的,有效的抗癌药物。Emitefur 可用于晚期胃癌患者。

乙嘧替氟名称

[ CAS 号 ]:
110690-43-2

[ 中文名 ]:
乙嘧替氟

[ 英文名 ]:
emitefur

[中文别名 ]:

依米替氟:BOF-A2

乙嘧替氟生物活性

[ 描述 ]:

Emitefur 是一种有口服活性的,有效的抗癌药物。Emitefur 可用于晚期胃癌患者。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Sugimachi K, et al. A phase II trial of a new 5-fluorouracil derivative, BOF-A2 (Emitefur), for patients with advanced gastric cancer. Surg Today. 2000;30(12):1067-72.

乙嘧替氟物理化学性质

[ 密度 ]:
1.52 g/cm3

[ 沸点 ]:
755.1ºC at 760 mmHg

[ 熔点 ]:
162-164°

[ 分子式 ]:
C₂₈H₁₉FN₄O₈

[ 分子量 ]:
558.47100

[ 闪点 ]:
410.5ºC

[ 精确质量 ]:
558.11900

[ PSA ]:
159.58000

[ LogP ]:
2.53668

[ 蒸汽压 ]:
1.09E-22mmHg at 25°C

[ 折射率 ]:
1.663

乙嘧替氟毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG9895000

CHEMICAL NAME :: Benzoic acid, 3-((3-(ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1 (2H)-pyrimidinyl) carbonyl)-, 6-(benzoyloxy)-3-cyano-2-pyridinyl ester

CAS REGISTRY NUMBER :: 110690-43-2

LAST UPDATED :: 199503

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C28-H19-F-N4-O8

MOLECULAR WEIGHT :: 558.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Blood - changes in spleen Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in spleen Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3640 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3640 mg/kg/1Y-I

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in spleen Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 7280 mg/kg/1Y-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in chlorine Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 2730 mg/kg/13W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 520 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 60 mg/L

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 18(Suppl 3),11,1993

乙嘧替氟制备

间苯二甲酰氯(Ⅰ)和化合物(Ⅱ)在三乙胺作用下，在二氧六环中回流，缩合得到化合物(Ⅲ)。再和化合物(Ⅳ)在三乙胺及乙腈中回流，即得乙嘧替氟。
上述合成中用到的化合物(Ⅳ)可由苯甲酰氯和3-氰基-2，6-二羟基吡啶，在三乙胺及二甲基甲酰胺中缩合而得。