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丙位戊内酯

丙位戊内酯用途

5-甲基二氢呋喃-2(3H)-酮是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

丙位戊内酯名称

[ CAS 号 ]:
108-29-2

[ 中文名 ]:
γ-戊内酯

[ 英文名 ]:
γ-Valerolactone

[中文别名 ]:

[英文别名 ]:

γ-Valeryllactone
Pentanoic acid, 4-hydroxy-, .γ.-lactone
gamma-valerolactone
2(3H)-Furanone, dihydro-5-methyl-
(±)-4-Methylbutyrolactone
4-Valerolactone
Dihydro-5-methyl-2(3H)-furanone
4,5-Dihydro-5-methyl-2(3H)-furanone
(±)-γ-Valerolactone
Valeric acid, 4-hydroxy-, γ-lactone

丙位戊内酯生物活性

[ 描述 ]:

5-甲基二氢呋喃-2(3H)-酮是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

γ-戊内酯是一种分析参考标准品,被归类为 γ-羟基戊酸的前药形式。1.本产品旨在用于研究和法医应用。

[参考文献]

[1]. Andresen-Streichert, H., Jungen, H., Gehl, A., et al. Uptake of gamma-valerolactone--detection of gamma-hydroxyvaleric acid in human urine samples. J. Anal. Toxicol. 37(4), 250-254 (2013).

丙位戊内酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
206.6±8.0 °C at 760 mmHg

[ 熔点 ]:
-31ºC

[ 分子式 ]:
C₅H₈O₂

[ 分子量 ]:
100.12

[ 闪点 ]:
81.1±0.0 °C

[ 精确质量 ]:
100.052429

[ PSA ]:
26.30000

[ LogP ]:
-0.27

[ 外观性状 ]:
无色至淡黄色透明液体

[ 蒸汽密度 ]:
3.45 (vs air)

[ 蒸汽压 ]:
0.2±0.4 mmHg at 25°C

[ 折射率 ]:
1.431

[ 储存条件 ]:
室温

[ 水溶解性 ]:
MISCIBLE

丙位戊内酯MSDS

丙位戊内酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU3580000

CHEMICAL NAME :: 2(3H)-Furanone, dihydro-5-methyl-

CAS REGISTRY NUMBER :: 108-29-2

BEILSTEIN REFERENCE NO. :: 0080420

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H8-O2

MOLECULAR WEIGHT :: 100.13

WISWESSER LINE NOTATION :: T5O CVTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8800 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2480 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/m3/7H/92D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 24400 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 201,431,1988

丙位戊内酯安全信息

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LU3580000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29322980

丙位戊内酯合成路线

丙位戊内酯上下游产品

丙位戊内酯上游产品

丙位戊内酯下游产品

丙位戊内酯制备

1.由不饱和羧酸通过闭环反应来合成，例如乙酰乙酸与硫酸共热，或乙酰丙酸在镍、铜等催化剂存在下加氢。

2.烟草：FC，9，18；BU，18。

丙位戊内酯海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

丙位戊内酯文献

Isolation and characterization of rat intestinal bacteria involved in biotransformation of (-)-epigallocatechin.

Arch. Microbiol. 196(10) , 681-95, (2014)

Two intestinal bacterial strains MT4s-5 and MT42 involved in the degradation of (-)-epigallocatechin (EGC) were isolated from rat feces. Strain MT4s-5 was tentatively identified as Adlercreutzia equol...

Bioavailability and catabolism of green tea flavan-3-ols in humans

Nutrition 26(11-12) , 1110-6, (2010)

Objective The aim of this study was to investigate green tea flavan-3-ol catabolism and plasma pharmacokinetic and urinary excretion by high-performance liquid chromatography with tandem mass spectrom...

Nonenzymatic sugar production from biomass using biomass-derived γ-valerolactone.

Science 343(6168) , 277-80, (2014)

Widespread production of biomass-derived fuels and chemicals will require cost-effective processes for breaking down cellulose and hemicellulose into their constituent sugars. Here, we report laborato...

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