2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-d-葡萄糖醇

用途

AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. Osteoarthritis patients have increased HEX activity in synovial fluid.

名称

[ CAS 号 ]:
105265-96-1

[ 中文名 ]:
2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-d-葡萄糖醇

[ 英文名 ]:
2-Acetamido-1,2-dideoxynojirimycin

[英文别名 ]:

5-acetamido-1,3,4-thiadiazole
2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol
Acetamide,N-1,3,4-thiadiazol-2-yl
2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol
2-acetylamino-1,3,4-thiadiazole
1,3,4-Thiadiazole,2-acetamido
X 134
1,2-dideoxy-2-acetamidonojirimycin
N-Acetyl-2-amino-1,3,4-thiadiazol
2-acetamido-1,2-dideoxynojirimycin

物理化学性质

[ 密度 ]:
1.35 g/cm3

[ 沸点 ]:
502.5ºC at 760 mmHg

[ 分子式 ]:
C₈H₁₆N₂O₄

[ 分子量 ]:
204.22400

[ 闪点 ]:
257.7ºC

[ 精确质量 ]:
204.11100

[ PSA ]:
101.82000

[ 蒸汽压 ]:
3.33E-12mmHg at 25°C

[ 折射率 ]:
1.565

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

合成路线

详细合成路线

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文献

Bovine N-acetyl-beta-D-glucosaminidase: affinity purification and characterization of its active site with nitrogen containing analogs of N-acetylglucosamine.

Biochim. Biophys. Acta 1080 , 89-95, (1991)

Two N-acetylglucosaminidases were isolated from bovine kidney with a three step procedure featuring affinity purification on 2-acetamido-1,2,5-trideoxy-1,5-iminoglucitol (2-acetamido-1,2-dideoxynojiri...

Suppression of beta-N-acetylglucosaminidase in the N-glycosylation pathway for complex glycoprotein formation in Drosophila S2 cells.

Glycobiology 19 , 301-308, (2009)

Most insect cells have a simple N-glycosylation process and consequently paucimannosidic or simple core glycans predominate. Previously, we have shown that paucimannosidic N-glycan structures are domi...

Purification and characterization of recombinant human alpha-N-acetylglucosaminidase secreted by Chinese hamster ovary cells.

Protein Expr. Purif. 19 , 202-211, (2000)

alpha-N-Acetylglucosaminidase (EC 3.2.1.50) is a lysosomal enzyme that is deficient in the genetic disorder Sanfilippo syndrome type B. To study the human enzyme, we expressed its cDNA in Lec1 mutant ...

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