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尼替西农

尼替西农用途

Nitisinone(SC0735)是4-羟基苯丙酮酸双加氧酶抑制剂。

尼替西农名称

[ CAS 号 ]:
104206-65-7

[ 中文名 ]:
尼替西农

[ 英文名 ]:
Nitisinone

[中文别名 ]:

[英文别名 ]:

nitisinonum
Orfadin
Nitisinone [INN]
nitisinona
Orfadin (TN)
Nitisone
Nitisinone

尼替西农生物活性

[ 描述 ]:

Nitisinone(SC0735)是4-羟基苯丙酮酸双加氧酶抑制剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Suwannarat, P., et al., Use of nitisinone in patients with alkaptonuria. Metabolism, 2005. 54(6): p. 719-28.

[2]. Santra, S. and U. Baumann, Experience of nitisinone for the pharmacological treatment of hereditary tyrosinaemia type 1. Expert Opin Pharmacother, 2008. 9(7): p. 1229-36.

[相关活性小分子]

尼替西农物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
486.2±45.0 °C at 760 mmHg

[ 熔点 ]:
129-131°C

[ 分子式 ]:
C₁₄H₁₀F₃NO₅

[ 分子量 ]:
329.228

[ 闪点 ]:
247.9±28.7 °C

[ 精确质量 ]:
329.051117

[ PSA ]:
97.03000

[ LogP ]:
1.37

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.535

[ 储存条件 ]:
2-8°C

尼替西农MSDS

详细MSDS(安全技术说明书)

尼替西农毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GV0766666

CHEMICAL NAME :: 1,3-Cyclohexanedione, 2-(2-nitro-4-trifluorobenzoyl)-

CAS REGISTRY NUMBER :: 104206-65-7

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4200 ug/kg/6W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Blood - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 141,439,1996

尼替西农安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2914700090

尼替西农海关

[ 海关编码 ]: 2914700090

[ 中文概述 ]:
2914700090 其他酮及醌的卤化、磺化衍生物（包括硝化和亚硝化衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

尼替西农文献

Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.

PLoS Biol. 9(7) , e1001099, (2011)

Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH⁻/⁻ mice) as a paradigm for orphan disorders, such as hereditary metabolic liver diseases, we evaluated...

Serum markers in alkaptonuria: simultaneous analysis of homogentisic acid, tyrosine and nitisinone by liquid chromatography tandem mass spectrometry.

Ann. Clin. Biochem. 52 , 597-605, (2015)

Alkaptonuria is a rare debilitating autosomal recessive disorder of tyrosine metabolism, where deficiency of homogentisate 1,2-dioxygenase results in increased homogentisic acid. Homogentisic acid is ...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

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