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顺式-5,8,11,14,17-二十碳五烯酸

顺式-5,8,11,14,17-二十碳五烯酸用途

Eicosapentaenoic acid (EPA)是一种ω-3脂肪酸。

顺式-5,8,11,14,17-二十碳五烯酸名称

[ CAS 号 ]:
10417-94-4

[ 中文名 ]:
全顺式二十碳五烯酸

[ 英文名 ]:
Eicosapentaenoic Acid

[中文别名 ]:

[英文别名 ]:

Eicosapentanoic acid
Ropufa 70
all-cis-5,8,11,14,17-Eicosapentaenoic Acid
Eicosapentaenoic acid, 5,8,11,14,17-(Z,Z,Z,Z,Z)-
eicosapentenoic acid
ALL CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID
icosapento
5C,8C,11C,14C,17C-EICOSAPENTAENOIC ACID
5,8,11,14,17-Icosapentaenoic Acid
92-PGM

顺式-5,8,11,14,17-二十碳五烯酸生物活性

[ 描述 ]:

Eicosapentaenoic acid (EPA)是一种ω-3脂肪酸。

[ 相关类别 ]:

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28(5): p. 525-42.

[2]. Huan, M., et al., Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry, 2004. 56(7): p. 490-6.

[相关活性小分子]

顺式-5,8,11,14,17-二十碳五烯酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
439.3±24.0 °C at 760 mmHg

[ 熔点 ]:
-54--53ºC(lit.)

[ 分子式 ]:
C₂₀H₃₀O₂

[ 分子量 ]:
302.451

[ 闪点 ]:
336.0±18.0 °C

[ 精确质量 ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.23

[ 外观性状 ]:
液体

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.513

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in methanol

顺式-5,8,11,14,17-二十碳五烯酸MSDS

顺式-5,8,11,14,17-二十碳五烯酸安全信息

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
26-36/37/39-45

[ 危险品运输编码 ]:
UN 3265

[ WGK德国 ]:
3

[ 海关编码 ]:
2916190090

顺式-5,8,11,14,17-二十碳五烯酸合成路线

顺式-5,8,11,14,17-二十碳五烯酸上下游产品

顺式-5,8,11,14,17-二十碳五烯酸上游产品

顺式-5,8,11,14,17-二十碳五烯酸下游产品

顺式-5,8,11,14,17-二十碳五烯酸制备

方法一、以鱼肝或碎鱼为原料
将鱼肝或碎鱼处理，得精制鱼油。将精制鱼油经尿素包合预浓缩后，在萃取压力为11-15MPa、萃取温度为35℃；精馏压力为11-15MPa、精馏温度为 40-85℃的条件下，EPA十DHA提纯至90%，采取两步分离法，EPA提纯至67%，DHA提纯至90%以上。
鱼油脂肪酸乙酯[超临界CO₂萃取]→[分离]EPA
方法二、以鲱鱼下脚料为原料
以鲱鱼下脚料为原料，制得多不饱和脂肪酸，其中EPA和DHA的总含量为64.8%。
方法三、以花生四烯酸为原料
以花生四烯酸为原料，经去饱和，制得EPA。
花生四烯酸[去饱和]→EPA
方法四、超临界多元流体精密精馏技术
方法五、淡碱水解法提取鱼油
方法六、钾法提取鱼油
结果(n=3)：鱼油提取率为24.4%；酸值为2.58；碘值为309；皂化值为178.7；过氧化值为0.070%；EPA含量为15.05%。

顺式-5,8,11,14,17-二十碳五烯酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

顺式-5,8,11,14,17-二十碳五烯酸文献

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...

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