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NSC12

NSC12用途

NSC 12是成纤维细胞生长因子2(FGF2)的细胞外陷阱,与FGF2结合并干扰其与FGFR1的相互作用。NSC12在体外和体内均能抑制不同FGF依赖性肿瘤细胞的增殖,且无全身毒性作用[1]。

NSC12名称

[ CAS 号 ]:
102586-30-1

[ 中文名 ]:
NSC12

[ 英文名 ]:
NSC-12

[英文别名 ]:

NSC-12

NSC12生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Ronca R, et al. Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. Cancer Cell. 2015 Aug 10;28(2):225-39.

NSC12物理化学性质

[ 分子式 ]:
C₂₄H₃₄F₆O₃

[ 分子量 ]:
484.51500

[ 精确质量 ]:
484.24100

[ PSA ]:
60.69000

[ LogP ]:
5.53300

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

NSC12毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4816000

CHEMICAL NAME :: Pregn-5-ene-3,20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-

CAS REGISTRY NUMBER :: 102586-30-1

LAST UPDATED :: 198612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C24-H34-F6-O3

MOLECULAR WEIGHT :: 484.58

WISWESSER LINE NOTATION :: L E5 B666 MUTJ A1 E1 FYQ1XQXFFFXFFF OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#09324