N-乙酰乙酰苯胺

N-乙酰乙酰苯胺用途

【用途一】
本品为染料、有机颜料、农药的中间体，用于合成中性黄色染料致性综合其GR，有机黄色颜料（如：C.I.1; C.I.12）的生产。也用于合成农药如：委锈灵等的生产。
【用途二】
主要用作染料中间体，用于制造吡唑啉酮、嫩黄5G、酸性络合黄GR、中性深黄GL、汉沙黄G、颜料黄G等染料
【用途三】
乙酰乙酰苯胺是杀菌剂拌种灵的中间体。
【用途四】
该品是染料、颜料及农药的中间体，用于制造吡唑啉酮、酸性络合黄GR、中性深黄GL，中性RL、颜料耐晒黄G等。

N-乙酰乙酰苯胺名称

[ CAS 号 ]:
102-01-2

[ 中文名 ]:
N-乙酰乙酰苯胺

[ 英文名 ]:
3-Oxo-N-phenylbutanamide

[中文别名 ]:

[英文别名 ]:

acetoacetamidobenzene
Linazol
Coupler 633
Acetoacetanilide
a-Acetylacetanilide
usafek-1239
2-acetylacetanilide
Acetoacetanilid
MFCD00008780
1V1VMR

N-乙酰乙酰苯胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
329.0±44.0 °C at 760 mmHg

[ 熔点 ]:
83-88 °C(lit.)

[ 分子式 ]:
C₁₀H₁₁NO₂

[ 分子量 ]:
177.200

[ 闪点 ]:
152.8±28.4 °C

[ 精确质量 ]:
177.078979

[ PSA ]:
46.17000

[ LogP ]:
1.43

[ 外观性状 ]:
白色至灰白色粉末

[ 蒸汽密度 ]:
6.1 (vs air)

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
5 g/L (20 ºC)

N-乙酰乙酰苯胺MSDS

详细MSDS(安全技术说明书)

N-乙酰乙酰苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK4200000

CHEMICAL NAME :: Acetoacetanilide

CAS REGISTRY NUMBER :: 102-01-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C10-H11-N-O2

MOLECULAR WEIGHT :: 177.22

WISWESSER LINE NOTATION :: 1V1VMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533750

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533572

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Blood - methemoglobinemia-carboxyhemoglobin

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534808-1

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 3925 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533572 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14024 mg/kg/14D-C

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0533572 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84311 No. of Facilities: 53 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1062 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84311 No. of Facilities: 50 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1108 (estimated)

N-乙酰乙酰苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
AK4200000

[ 海关编码 ]:
2924299090

N-乙酰乙酰苯胺合成路线

详细合成路线

N-乙酰乙酰苯胺上下游产品

N-乙酰乙酰苯胺上游产品

N-乙酰乙酰苯胺下游产品

N-乙酰乙酰苯胺制备

由双乙烯酮与苯胺作用而得：将苯胺与双乙烯酮在0-15℃温度下反应，生成乙酰乙酰苯胺，再经过滤，烘干得成品。此法与用酰乙酸乙酯的酰化相比，双乙烯酮的酰化具有工艺简单、收率高、质量好等优点。原料消耗定额：苯胺（99.5)548kg/t，双乙烯酮(96%)501kg/t。实验室制备可按下法操作在500ml三口烧瓶中放46g(0.5 mol)无水苯胺，125ml无水苯。在搅拌下滴加双乙烯酮的苯溶液(42g，0.5mol双乙烯酮加75ml苯)，半小时内滴完.将反应物回流1h，然后蒸除苯.剩余物用热的乙醇水溶液溶解(50%乙醇水溶液500ml)。冷却析出乙酰乙酰苯胺，过滤。滤液用250ml冲稀，冷却，过滤还可得到部分产品,共得65g，产率75%，熔点82-83.5℃。将粗品用300ml，50%的乙醇重结晶，得纯品55g，熔点84-85℃。

其制备方法是在反应釜内开动搅拌，降温0～15℃，按一定的流量比通过流量计同时加入苯胺和双乙烯酮，在2h左右加完，然后在10～15℃搅拌2 h，经吸滤干燥而得成品。

N-乙酰乙酰苯胺海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-乙酰乙酰苯胺文献

Kinetics and mechanisms of reactions between H2O2 and copper and copper oxides.

Dalton Trans. 44 , 16045-51, (2015)

One of the main challenges for the nuclear power industry today is the disposal of spent nuclear fuel. One of the most developed methods for its long term storage is the Swedish KBS-3 concept where th...

Acetoacetanilides as masked isocyanates: facile and efficient synthesis of unsymmetrically substituted ureas.

Org. Lett. 12 , 4220-4223, (2010)

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed. By the reactions of acetoacetanilides with various amines including primary/secondary amines...

Massive screening yields novel and selectiveTrypanosoma cruzitriosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity

Eur. J. Med. Chem. 45 , 5767-72, (2010)

Triosephosphate isomerase from Trypanosoma cruzi (TcTIM), an enzyme in the glycolytic pathway that exhibits high catalytic rates of glyceraldehyde-3-phosphate- and dihydroxyacetone-phosphate-isomeriza...

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