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DL-α-生育酚

DL-α-生育酚用途

DL-alpha-Tocopherol 是一种合成维生素 E,具有抗氧化作用。DL-alpha-Tocopherol 能保护皮肤成纤维细胞免受紫外线的细胞毒性作用。

DL-α-生育酚名称

[ CAS 号 ]:
10191-41-0

[ 中文名 ]:
维生素 E

[ 英文名 ]:
Vitamin E

[中文别名 ]:

[英文别名 ]:

DL-TOCOPHEROL
dl-alpha-Tocopherol(E)
ecyl)
ephanyl
alpha-Tocopherol
(±)-α-Tocopherol
vitamin
A-TOCOPHEROL
Irganox E 201
MFCD00072051

DL-α-生育酚生物活性

[ 描述 ]:

DL-alpha-Tocopherol 是一种合成维生素 E,具有抗氧化作用。DL-alpha-Tocopherol 能保护皮肤成纤维细胞免受紫外线的细胞毒性作用。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kondo S, et al. Protective effect of dl-alpha-tocopherol on the cytotoxicity of ultraviolet B against human skin fibroblasts in vitro. Photodermatol Photoimmunol Photomed. 1990 Aug;7(4):173-7.

DL-α-生育酚物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
485.9±0.0 °C at 760 mmHg

[ 熔点 ]:
2-4°C

[ 分子式 ]:
C₂₉H₅₀O₂

[ 分子量 ]:
430.706

[ 闪点 ]:
210.2±24.4 °C

[ 精确质量 ]:
430.381073

[ PSA ]:
29.46000

[ LogP ]:
11.90

[ 外观性状 ]:
微黄绿色,透明粘稠液体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.495

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：不溶；易溶于：乙醇；可溶于：丙酮,氯仿,乙醚

DL-α-生育酚MSDS

DL-α-生育酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GA8746000

CHEMICAL NAME :: 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-

CAS REGISTRY NUMBER :: 10191-41-0

BEILSTEIN REFERENCE NO. :: 0094012

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C29-H50-O2

MOLECULAR WEIGHT :: 430.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 25,163,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1133 No. of Facilities: 104 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 555 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1133 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 114 (estimated)

DL-α-生育酚安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
GA8746000

DL-α-生育酚合成路线

DL-α-生育酚上下游产品

DL-α-生育酚上游产品

DL-α-生育酚下游产品

DL-α-生育酚制备

由1,2,4-三甲苯为原料经碘化、硝化、还原、氧化得2,3,5-三甲基苯醌，然后还原，与叶绿醇等缩合制得。

DL-α-生育酚文献

Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.

Pharm. Dev. Technol. 20(2) , 169-75, (2015)

The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches....

Development of novel formulations to enhance in vivo transdermal permeation of tocopherol.

Acta. Pharm. 64(3) , 299-309, (2014)

Tocopherol represents a big challenge for transdermal permeation owing to its extreme hydrophobicity and large molecular mass. The aim of the present study was to develop alpha-tocopherol (T) topical ...

Coffee silverskin: a possible valuable cosmetic ingredient.

Pharm. Biol. 53(3) , 386-94, (2015)

Currently, there is a great tendency in cosmetic area to use natural extracts. Coffee silverskin (CS) is the most abundant solid by-product generated during roasting of coffee processing.To evaluate d...

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