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弯孢霉菌素

弯孢霉菌素用途

Curvularin 是可从 Curvularia lunata 中提取得到的一种真菌代谢物和强效的霉菌毒素,能抑制细胞因子诱导的 NO 合成酶,其IC50 值为 9.5 µM。

弯孢霉菌素名称

[ CAS 号 ]:
10140-70-2

[ 中文名 ]:
弯抱霉菌素

[ 英文名 ]:
Curvularin

[英文别名 ]:

curvularin

弯孢霉菌素生物活性

[ 描述 ]:

Curvularin 是可从 Curvularia lunata 中提取得到的一种真菌代谢物和强效的霉菌毒素,能抑制细胞因子诱导的 NO 合成酶,其IC50 值为 9.5 µM。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[ 靶点 ]

IC50: 9.5 µM (iNOS)[2].

[参考文献]

[1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122.

[2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91.

弯孢霉菌素物理化学性质

[ 密度 ]:
1.2g/cm3

[ 沸点 ]:
557ºC at 760mmHg

[ 熔点 ]:
205-207 °C

[ 分子式 ]:
C₁₆H₂₀O₅

[ 分子量 ]:
292.32700

[ 闪点 ]:
207.9ºC

[ 精确质量 ]:
292.13100

[ PSA ]:
83.83000

[ LogP ]:
2.71880

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
5.18E-13mmHg at 25°C

[ 折射率 ]:
1.54

[ 储存条件 ]:
-20°C，密封，干燥，避光

弯孢霉菌素MSDS

详细MSDS(安全技术说明书)

弯孢霉菌素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

弯孢霉菌素文献

Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa.

J. Nat. Prod. 76(11) , 2145-9, (2013)

Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicill...

Metabolite production by differentUlocladiumspecies

Int. J. Food Microbiol. 126(1-2) , 172-9, (2008)

Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agent...

[Molecular basis of probes for cytoskeletal proteins].

Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993)

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