4,4'-二氨基二苯甲烷

4,4'-二氨基二苯甲烷用途

【用途一】
主要用于轮胎、胎侧、帘布层、内胎、输送管、胶管、三角带等橡胶制品中
【用途二】
用于生产绝缘材料、染料、二异氰酸酯、聚氨酯橡胶、H级粘合剂、环氧树脂固化剂等
【用途三】
用作分析试剂，也用于有机合成
【用途四】
制造染料，测定钨及硫酸盐，橡胶的抗氧剂和防老剂。

4,4'-二氨基二苯甲烷名称

[ CAS 号 ]:
101-77-9

[ 中文名 ]:
4,4'-二氨基二苯甲烷

[ 英文名 ]:
4,4′-methylenedianiline

[中文别名 ]:

4,4’-二氨基二苯基甲烷

[英文别名 ]:

Curithane
bis-p-aminophenylmethane
EINECS 202-974-4
4,4’-Diaminodiphenylmethane
p-Toluidine, α-(p-aminophenyl)-
MDA
bis(4-aminophenyl) methane
HT 972
4,4′-methylenedianiline
Benzenamine, 4,4'-methylenebis-

4,4'-二氨基二苯甲烷物理化学性质

[ 密度 ]:
1.15

[ 沸点 ]:
398-399 ºC (768 torr)

[ 熔点 ]:
88-92 ºC

[ 分子式 ]:
C₁₃H₁₄N₂

[ 分子量 ]:
198.264

[ 闪点 ]:
221 ºC

[ 精确质量 ]:
198.115692

[ PSA ]:
52.04000

[ LogP ]:
1.64

[ 外观性状 ]:
白色至黄色或米色片或晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.660

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
微溶. <0.1 g/100 mL at 19 ºC

4,4'-二氨基二苯甲烷MSDS

4,4'-二氨基二苯甲烷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY5425000

CHEMICAL NAME :: Aniline, 4,4'-methylenedi-

CAS REGISTRY NUMBER :: 101-77-9

BEILSTEIN REFERENCE NO. :: 0474706

LAST UPDATED :: 199806

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: C13-H14-N2

MOLECULAR WEIGHT :: 198.29

WISWESSER LINE NOTATION :: ZR D1R DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 8420 ug/kg

TOXIC EFFECTS :: Behavioral - rigidity (including catalepsy) Liver - jaundice, other or unclassified Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 517 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 745 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 74 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16800 mg/kg/40W-C

TOXIC EFFECTS :: Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6972 mg/kg/12W-I

TOXIC EFFECTS :: Liver - other changes Blood - changes in spleen Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 456 mg/kg/15W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - interstitial nephritis Blood - normocytic anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg/I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg/I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 108,225,1983 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.81 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,347,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 39,347,1986 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: DE85-017376 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.8 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.81 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.8 mg/m3) JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.8 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 4,4'-METHYLENEDIANILINE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83609 No. of Facilities: 363 (estimated) No. of Industries: 16 No. of Occupations: 27 No. of Employees: 9163 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83609 No. of Facilities: 741 (estimated) No. of Industries: 25 No. of Occupations: 30 No. of Employees: 15170 (estimated) No. of Female Employees: 3407 (estimated)

4,4'-二氨基二苯甲烷安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H317-H341-H350-H370-H373-H411

[ 警示性声明 ]:
P201-P260-P273-P280-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R39/23/24/25;R43;R45;R48/20/21/22;R51/53

[ 安全声明 (欧洲) ]:
S53-S45-S61

[ 危险品运输编码 ]:
UN 2651 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
BY5425000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2921590033

4,4'-二氨基二苯甲烷合成路线

4,4'-二氨基二苯甲烷上下游产品

4,4'-二氨基二苯甲烷上游产品

4,4'-二氨基二苯甲烷下游产品

4,4'-二氨基二苯甲烷制备

以苯胺及甲醛为原料，在盐酸中于50-60℃下缩合，再用碳酸钠溶液中和，经分离、蒸馏、结晶而得成品。制备实例：将2mol盐酸、400ml水和2mol新蒸过的苯胺一起搅拌冷却，于15℃加入1mol40%的甲醛溶液，加热，在55-60℃反应4h。反应产物用碳酸钠溶液中和并碱化。进行水蒸气蒸馏，直至馏分中不再有苯胺为止。将沉淀物加稍过量的盐酸重新溶解，用稀氨水分步沉淀，将最先沉淀的树脂状物滤去，向滤液加入过量氨水，得白色结晶沉淀；过滤，得产品112g,产率57%。进一步提纯可采用乙醇或水重结晶。

4,4'-二氨基二苯甲烷海关

[ 海关编码 ]: 2921590033

[ 中文概述 ]:
2921590033 4,4’-二氨基二苯基甲烷。监管条件:X(有毒化学品环境管理放行通知单)。增值税率:17.0%。退税率:13.0%。最低关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: X.有毒化学品环境管理放行通知单

[ Summary ]:
2921590033 4,4'-methylenedianiline。supervision conditions:x(environment control release notice for poisonous chemicals)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:6.5%。general tariff:30.0%

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