无水氯化镧

无水氯化镧用途

1）主要用作制备石油裂化的催化剂，也可作提取单一稀土产品或冶炼富集混合稀土金属的原料。
2）用于制取金属镧和石油催化剂原料，还可用于贮氢电池材料。

无水氯化镧作用

氯化镧在医药领域具有一定作用。如研究表明氯化镧对内毒素（LPS）体内效应的拮抗作用，对寻找新的有效内毒素拮抗剂具有一定影响，为防治内毒素血症提供实验依据。试验观察不同方式给予氯化镧处理对半数致死量LPS 17.5mg/kg攻击小鼠的死亡率的影响，观察氯化镧对LPS 12.5 mg/kg攻击后小鼠血浆肿瘤坏死因α（TNFα）及肝脏TNFα mRNA表达水平的变化、胸腺细胞凋亡状况、肝肺的病理损伤状况的影响，结果显示经5、10、20 mg/kg氯化镧处理的半数致死量LPS攻击小鼠的死亡率分别为0、0和8%，明显低于对照组的死亡率67%。10 mg/kg氯化镧预防性给药，半数致死量LPS攻击小鼠后死亡率为20%，明显低于对照组死亡率(55%)；经氯化镧处理的内毒素血症小鼠血浆TNFα含量为0.44± 0.215 ng/ml，肝组织TNF-α mRNA表达量为(3.9± 0.6)× 105拷贝/μg RNA，明显低于内毒素血症小鼠[0.99± 0.24 ng/ml，(1.9± 0.3)× 107拷贝/μg RNA]；经氯化镧处理的内毒素血症小鼠胸腺细胞DNA片段百分率为30.35%± 6.42%，明显低于未处理小鼠（55.38%±3.88%）；内毒素血症小鼠胸腺细胞凋亡百分率为15.56%± 0.59%，明显高于氯化镧处理小鼠（6.05%±0.71%）；形态学检查显示氯化镧能够减轻内毒素所造成的肝肺病理损伤。因此氯化镧可结合LPS，降低LPS毒性，对致死量LPS攻击小鼠具有保护作用。，能显著降低内毒素血症小鼠TNFα的分泌及肝组织中的TNFα mRNA的表达，抑制胸腺细胞的凋亡，减轻LPS对机体造成的损伤。

无水氯化镧名称

[ CAS 号 ]:
10099-58-8

[ 中文名 ]:
氯化镧

[ 英文名 ]:
Lanthanum(III) chloride

[中文别名 ]:

[英文别名 ]:

lanthanum chloride
Lanthanum trichloride
EINECS 233-237-5
lanthanum(III) chloride
MFCD00011068

无水氯化镧物理化学性质

[ 密度 ]:
3.84 g/mL at 25ºC

[ 沸点 ]:
1812ºC

[ 熔点 ]:
860 ºC

[ 分子式 ]:
Cl₃La

[ 分子量 ]:
245.264

[ 闪点 ]:
1000ºC

[ 精确质量 ]:
243.812912

[ LogP ]:
2.06850

[ 外观性状 ]:
白色粉末或无色晶体

[ 储存条件 ]:
室温，干燥，密封

[ 稳定性 ]:
Stability

无水氯化镧MSDS

详细MSDS(安全技术说明书)

无水氯化镧毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OE4375000

CHEMICAL NAME :: Lanthanum chloride

CAS REGISTRY NUMBER :: 10099-58-8

LAST UPDATED :: 199701

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: Cl3-La

MOLECULAR WEIGHT :: 245.26

WISWESSER LINE NOTATION :: LA G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2424 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 694 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 112 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 112 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 5 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

MUTATION DATA

TEST SYSTEM :: Mammal - domestic

DOSE/DURATION :: 5 mg/kg

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,143,1973 *** REVIEWS *** TOXICOLOGY REVIEW JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 54,663,1965

无水氯化镧安全信息

[ 符号 ]:

GHS05, GHS07, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H290-H317-H318-H411

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN3264

[ WGK德国 ]:
2

[ RTECS号 ]:
OE4375000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2846902300

无水氯化镧合成路线

详细合成路线

无水氯化镧上下游产品

无水氯化镧上游产品

无水氯化镧下游产品

无水氯化镧制备

1.含水氯化物装在硬质玻璃管中的石英舟里，用减压装置(维持水银柱高25cm)以1cm3/s的速度通入纯净、干燥的HCl气体，在70℃下维持3h，然后逐步升温到160℃，维持1～2h，再慢慢上升到250℃，趁热打开炉子转移石英管到保干器(浓硫酸做干燥剂)里面，冷却，产物转移到热的、干燥的试剂瓶中，迅速密封即可。

2.按化学计量关系称取反应物，反应物装在悬于电炉中的石英管(d=13～25mm,l=7～25cm)中，选择的电炉应能使样品管各个部位的温度尽可能一致。反应管入口与蒸馏烧瓶的侧口相连(蒸馏烧瓶连有聚四氟乙烯管子)，出口与冷凝接收器(连有聚乙烯管子)相连，每做一次实验后聚乙烯管都需要更换，而聚四氟乙烯管不会受反应的影响(装置如图）

以0.22～0.27g/min·cm的速度从样品管滴加CCl4到蒸馏烧瓶中。可通过蒸馏烧瓶上聚四氟乙烯管上的螺旋夹子调整CCl4的流速。用电热罩维持蒸馏烧瓶的温度为100℃，使用电热带以维持预热部分(连接蒸馏烧瓶与反应管的侧管部分)的温度在120℃。

反应炉温度按下列步骤进行控制：500℃ 6h，550℃ 15h，600～650℃ 8h。

反应完成后，由惰性气体入口通入Ar或者其他惰性气体。断开反应管，配上活塞，连接真空体系，抽真空，密封保存。

无水氯化镧海关

[ 海关编码 ]: 2846902300

无水氯化镧文献

A dendrimer-like hyper branched chitosan beads toward fluoride adsorption from water.

Int. J. Biol. Macromol. 78 , 280-6, (2015)

The present study reports a novel approach for the preparation of polyamidoamine grafted chitosan beads (PAAGCB) via Michael addition followed by protonation of PAAGCB to get protonated PAAGCB (H(+)-P...

Sugar-metal ion interactions: the coordination behaviors of lanthanum with erythritol.

Carbohydr. Res. 361 , 12-8, (2012)

Three novel lanthanum chloride-erythritol complexes (LaCl(3)·C(4)H(10)O(4)·5H(2)O (LaE(I)), LaCl(3)·C(4)H(10)O(4)·3H(2)O (LaE(II)), and LaCl(3)·1.5C(4)H(10)O(4) (LaE(III)) were synthesized and charact...

Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca²⁺ and Bcl-2 family.

Biol. Trace Elem. Res. 152(1) , 125-34, (2013)

As a representative element of lanthanide, lanthanum has been widely used in various fields and eventually entered environment and accumulated in human body. Epidemiological and experimental evidences...

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