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5-溴吲哚

5-溴吲哚用途

【用途一】
用作医药中间体

5-溴吲哚名称

[ CAS 号 ]:
10075-50-0

[ 中文名 ]:
5-溴吲哚

[ 英文名 ]:
5-Bromoindole

[中文别名 ]:

5-溴代吲哚

[英文别名 ]:

5-Br-indole
5-Bromo-1H-indole
5-bromo-indole
EINECS 233-208-7
5-BI
5-broMo-2H-indole
1H-Indole, 5-bromo-
5-bromonindole
5-Bromide indole
5-indolyl bromide

5-溴吲哚生物活性

[ 描述 ]:

5-溴吲哚是一种化学中间体,可用于合成GSK-3抑制剂和抗癌剂[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

5-溴吲哚物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
316.9±15.0 °C at 760 mmHg

[ 熔点 ]:
90-92 °C(lit.)

[ 分子式 ]:
C₈H₆BrN

[ 分子量 ]:
196.044

[ 闪点 ]:
145.5±20.4 °C

[ 精确质量 ]:
194.968353

[ PSA ]:
15.79000

[ LogP ]:
3.00

[ 外观性状 ]:
白色至米色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.712

[ 储存条件 ]:
-20°C

5-溴吲哚MSDS

5-溴吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
29339990

5-溴吲哚合成路线

5-溴吲哚上下游产品

5-溴吲哚上游产品

5-溴吲哚下游产品

5-溴吲哚海关

[ 海关编码 ]: 29339990

5-溴吲哚文献

Identification of novel CYP2A6 inhibitors by virtual screening

Bioorg. Med. Chem. 19 , 7186-93, (2011)

The human CYP2A6 enzyme metabolises several xenobiotics including nicotine, the addictive component in tobacco. Reduced activity of CYP2A6, either for genetic reasons or by administering inhibitors of...

Rational design of novel CYP2A6 inhibitors.

Bioorg. Med. Chem. 22(23) , 6655-64, (2015)

Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by e...

Untargeted Screening and Distribution of Organo-Bromine Compounds in Sediments of Lake Michigan.

Environ. Sci. Technol. 50 , 321-30, (2016)

Previously unreported natural and synthetic organo-bromine compounds (NSOBCs) have been found to contribute more than 99% of total organic bromine (TOB) in environmental matrices. We recently develope...

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