Hydrogen peroxide-triggered gene silencing in mammalian cells through boronated antisense oligonucleotides

10.1039/C7SC04318J

2017-12-06

Hydrogen peroxide (H2O2) is a reactive oxygen species (ROS) involved in various diseases, including neurodegeneration, diabetes, and cancer. Here, we introduce a new approach to use H2O2 to modulate specific gene expression in mammalian cells. H2O2-responsive...

Polarisation effects on the solvation properties of alcohols

10.1039/C7SC04890D

2017-12-06

Alcohol solvents are significantly more polar than expected based on the measured H-bonding properties of monomeric alcohols in dilute solution. Self-association of alcohols leads to formation of cyclic aggregates and linear polymeric chains that have a diffe...

Mechanochemistry of the mechanical bond

10.1039/C7SC04200K

2017-12-04

Strong and stable under tension? In this review we present the recent efforts investigating the mechanochemical properties of interlocked structures by atomic force microscopy and polymer mechanochemistry.

Quantum optical emulation of molecular vibronic spectroscopy using a trapped-ion device

10.1039/C7SC04602B

2017-12-01

Molecules are one of the most demanding quantum systems to be simulated by quantum computers due to their complexity and the emergent role of quantum nature. The recent theoretical proposal of Huh et al. (Nature Photon., 9, 615 (2015)) showed that a multi-pho...

Excited state electron and energy relays in supramolecular dinuclear complexes revealed by ultrafast optical and X-ray transient absorption spectroscopy

10.1039/C7SC04055E

2017-11-28

The kinetics of photoinduced electron and energy transfer in a family of tetrapyridophenazine-bridged heteroleptic homo- and heterodinuclear copper(I) bis(phenanthroline)/ruthenium(II) polypyridyl complexes were studied using ultrafast optical and multi-edge ...

Design of DNA nanostructure-based interfacial probes for the electrochemical detection of nucleic acids directly in whole blood

10.1039/C7SC04663D

2017-11-28

Here we report a robust and sensitive DNA nanostructure-based electrochemical (E-nanoDNA) sensor that utilizes tetrahedral DNA nanostructures (TDNs) as an interfacial probe to detect biomolecules in a single-step procedure. In this study, we have firstly demo...

Establishment of a universal and rational gene detection strategy through three-way junction-based remote transduction

10.1039/C7SC03190D

2017-11-27

The polymerase chain reaction and many isothermal amplifications are able to achieve super gene amplification. Unfortunately, most commonly-used transduction methods, such as dye staining and Taqman-like probing, still suffer from shortcomings including false...

Organocatalytic nitrenoid transfer: metal-free selective intermolecular C(sp3)–H amination catalyzed by an iminium salt

10.1039/C7SC03968A

2017-11-27

This report details the first organocatalytic method for nitrenoid transfer and its application to intermolecular, site-selective C(sp3)–H amination. The method utilizes a trifluoromethyl iminium salt as the catalyst, iminoiodinanes as the nitrogen source, an...

Cobalt-catalyzed regioselective stereoconvergent Markovnikov 1,2-hydrosilylation of conjugated dienes

10.1039/C7SC04002D

2017-11-27

We report the first stereoconvergent Markovnikov 1,2-hydrosilylation of conjugated dienes using catalysts generated from bench-stable Co(acac)2 and phosphine ligands. A wide range of E/Z-dienes underwent this Markovnikov 1,2-hydrosilylation in a stereoconverg...

Ni-catalysed regioselective 1,2-diarylation of unactivated olefins by stabilizing Heck intermediates as pyridylsilyl-coordinated transient metallacycles

10.1039/C7SC04351A

2017-11-27

We report a Ni-catalysed diarylation of unactivated olefins in dimethylpyridylvinylsilane by intercepting Heck C(sp3)–NiX intermediates, derived from aryl halides, with arylzinc reagents. This approach utilizes a modifiable pyridylsilyl moiety as a coordinati...