Electrochemical Imaging of Cells and Tissues



The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of single ...

Iron-catalyzed urea synthesis: dehydrogenative coupling of methanol and amines



Substituted ureas have numerous applications but their synthesis typically requires the use of highly toxic starting materials. Herein we describe the first base-metal catalyst for the selective synthesis of symmetric ureas via the dehydrogenative coupling of...

Why One Can Expect Large Rectification in Molecular Junctions Based on Alkane Monothiols and Why Rectification Is So Modest



Many attempts to obtain high current rectification ratios (RR) in molecular electronics are triggered by a potentiometer rule argument, which predicts that a strongly asymmetric location of the dominant molecular orbital yields large RR-values. Invoking this ...

9,10-Azaboraphenanthrene-Containing Small Molecules and Conjugated Polymers: Synthesis and Their Application in Chemodosimeters for the Ratiometric Detection of Fluoride Ions



The introduction of main group elements into conjugated scaffold is emerging as a key route to novel optoelectronic materials. Herein, an efficient and versatile way to synthesize polymerizable 9,10-azaboraphenanthrene (BNP)-containing monomer by aromaticity-...

Aldehyde group driven aggregation-induced enhanced emission in naphthalimides and its application for ultradetection of hydrazine on multiple platforms



Restriction of intramolecular motion (RIM) of rigid aromatic cores is the most universal mechanism so far that can successfully explain almost all AIE/AIEEgenic systems. By designing two novel naphthalimide derivatives (NIB and NIBD), we experimentally demons...

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging



We describe the development of a bifunctional linker that simultaneously allows site-specific protein modification and palladium-mediated bioorthogonal decaging. This was enabled by a thioether binding motif in the propargyl carbamate linker and a readily ava...

Nontrigonal Constraint Enhances 1,2-Addition Reactivity of Phosphazenes



The syntheses and 1,2-addition reactivities of nontrigonal phosphazenes supported by trianionic tricoordinating chelates of the type L3P=Ndipp (3: L3 = N[CHC(tBu)O]23–; 4: L3 = N(o-NMeC6H4)23–; dipp = 2,6-diisopropylphenyl) are reported. These compounds are c...

Diastereoisomers of L-Proline-linked trityl-nitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions



The exchange (J) interaction of organic biradicals is a crucial factor controlling their physiochemical properties and potential applications, and can be modulated by changing the nature of the linker. In the present work, we for the first time demonstrate th...

Acidity and basicity interplay in amides and imides self–association



Amides dimerise more strongly than imides despite their lower acidity. Such unexpected result has been rationalised in terms of the Jorgensen Secondary Interactions Hypothesis (JSIH) that involve the spectator (C=OS) and H-bonded (C=OHB) carbonyl groups in im...

The Bethe–Salpeter formalism with polarisable continuum embedding: reconciling linear-response and state-specific features



The Bethe–Salpeter equation (BSE) formalism has been recently shown to be a valuable alternative to time-dependent density functional theory (TD-DFT) with the same computing time scaling with system size. In particular, problematic transitions for TD-DFT such...