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ProteoFind: A script for finding proteins that are suitable for chemical synthesis
10.1016/j.tet.2018.03.030 2018-03-15 ProteoFind is a computational script for finding proteins that are suitable for fragment ligation-based chemical synthesis. This paper describes the development and case studies of ProteoFind, which searches protein lists obtained from the UniProt website. It... |
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Palladium(II)-N-heterocyclic carbene-catalyzed direct C2- or C5-arylation of thiazoles with aryl bromides
10.1016/j.tet.2018.03.026 2018-03-14 Herein we report, a series of new benzimidazolium chlorides as N-heterocyclic carbene (NHC) ligand and their corresponding palladium(II)-NHC complexes with the general formula [PdCl2(NHC)2] were synthesized. All new compounds were characterized by 1H NMR, 13C... |
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A mechanistic investigation of an Iridium-catalyzed asymmetric hydrogenation of pyridinium salts
10.1016/j.tet.2018.03.031 2018-03-14 NMR studies of the catalyst, deuteration experiments, mass spectrometry, and isolation and characterization of intermediates, allow us to propose an outer-sphere mechanism for the Iridium-catalyzed asymmetric hydrogenation of N-alkyl-2-arylpyridinium salts. |
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Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small molecule–protein interactions
10.1016/j.tet.2018.03.024 2018-03-14 We report the synthesis of an electronically-tuned minimally interfering photo-affinity label (MI-PAL), a compact five-carbon tag functionalized with an alkyl diazirine and alkyne handle. MI-PAL is compatible with protein photo-conjugation, click chemistry an... |
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Enhanced enantioselective oxidation of olefins catalyzed by Mn-porphyrin immobilized on graphene oxide
10.1016/j.tet.2018.03.027 2018-03-13 An efficient enantioselective heterogeneous catalyst, GO-[Mn(TPyP)tart], was prepared by covalent attachment of Mn(III) complex of H2TPyP via the propyl linkage to graphene oxide (GO) nanosheet and using chiral tartrate counter ion. The catalyst was character... |
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Asymmetric ring-opening reaction of azabenzonorbornadienes with phenols promoted by palladium/(R,R)-DIOP complex
10.1016/j.tet.2018.03.029 2018-03-13 An efficient asymmetric ring opening reaction of azabenzonorbornadienes with various phenols using Palladium/(R,R)-DIOP complex has been demonstrated, the reaction afforded the corresponding products in excellent yields (80–95%) with moderate enantioselectivi... |
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Streptopyrazinones A−D, rare metabolites from marine-derived Streptomyces sp. ZZ446
10.1016/j.tet.2018.03.028 2018-03-13 Secondary metabolites from marine-associated actinomycetes are important source for the discovery of novel bioactive compounds. In this study, an actinomycete Streptomyces sp. ZZ446 was isolated from coastal soils and different media were used to culture this... |
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Conformational search and spectroscopic analysis of bis-β-D-glucopyranosyl azacrown derivative
10.1016/j.tet.2018.03.025 2018-03-12 1,10-N,N′-bis-(β-D-ureidoglucopyranosyl)-4,7,13-trioxa-1,10-diazacyclopentadecane is a new, recently synthesized compound, which exhibits complexation ability towards drugs. In the present study various theoretical methods, including molecular mechanics, comp... |
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Synthesis of N,N′-bridged azacalixarenes
10.1016/j.tet.2018.03.002 2018-03-11 The one-pot reaction between bis(hydroxymethyl)phenol derivatives and diamines or triamines afforded novel azacalixarenes with bridged structures. Basket-type macrocycles of cone conformations, molecules that contained two aza[3.1.1.1]calixarene skeletons con... |
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Diastereoselective approach to trans-5-hydroxy-6-substitutedethanone-2-piperidinones: Scalable syntheses of (+)-febrifugine and (+)-halofuginone
10.1016/j.tet.2018.03.022 2018-03-10 An efficient diastereoselective approach to access trans-5-hydroxy-6-substitutedethanone-2-piperidinones skeleton has been developed through sequential addition-deprotection-cyclization process involving aldimine 6 with substituted acetones. The diastereosele... |