|
Publisher Correction: ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma
10.1038/s41467-018-03710-1 2018-04-06 In the original version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include the following: The National Basic Research Program (2015CB553602 to J.L.), the National Natural ... |
|
|
In situ X-ray scattering observation of two-dimensional interfacial colloidal crystallization
10.1038/s41467-018-03767-y 2018-04-06 Charged colloids at interfaces hold such a simple configuration that their interactions are supposed to be fully elucidated in the framework of classical electrostatics, yet the mysterious existence of attractive forces between these like-charged particles ha... |
|
|
Rescue of conformational dynamics in enzyme catalysis by directed evolution
10.1038/s41467-018-03562-9 2018-04-03 Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is recognized as important, but due to the inherent flexibility of biological macromolec... |
|
|
Experimentally quantifying anion polarizability at the air/water interface
10.1038/s41467-018-03598-x 2018-04-03 The adsorption of large, polarizable anions from aqueous solution on the air/water interface controls important atmospheric chemistry and is thought to resemble anion adsorption at hydrophobic interfaces generally. While the favourability of adsorption of suc... |
|
|
Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum
10.1038/s41467-018-03683-1 2018-04-03 Drugs of abuse, including alcohol, ablate the expression of specific forms of long-term synaptic depression (LTD) at glutamatergic synapses in dorsal striatum (DS), a brain region involved in goal-directed and habitual behaviors. This loss of LTD is associate... |
|
|
Prokaryotic nanocompartments form synthetic organelles in a eukaryote
10.1038/s41467-018-03768-x 2018-04-03 Compartmentalization of proteins into organelles is a promising strategy for enhancing the productivity of engineered eukaryotic organisms. However, approaches that co-opt endogenous organelles may be limited by the potential for unwanted crosstalk and disrup... |
|
|
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
10.1038/s41467-018-03775-y 2018-04-03 Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance. Knockout of Lpl or its obligatory cof... |
|
|
Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers
10.1038/s41467-018-03730-x 2018-04-03 To realize the full potential of immunotherapy, it is critical to understand the drivers of tumor infiltration by immune cells. Previous studies have linked immune infiltration with tumor neoantigen levels, but the broad applicability of this concept remains ... |
|
|
Metal-organic frameworks for precise inclusion of single-stranded DNA and transfection in immune cells
10.1038/s41467-018-03650-w 2018-04-03 Effective transfection of genetic molecules such as DNA usually relies on vectors that can reversibly uptake and release these molecules, and protect them from digestion by nuclease. Non-viral vectors meeting these requirements are rare due to the lack of spe... |
|
|
Photonic zero mode in a non-Hermitian photonic lattice
10.1038/s41467-018-03822-8 2018-04-03 Zero-energy particles (such as Majorana fermions) are newly predicted quasiparticles and are expected to play an important role in fault-tolerant quantum computation. In conventional Hermitian quantum systems, however, such zero states are vulnerable and even... |