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Novel 3D Hybrid Nanofiber Aerogels Coupled with BMP‐2 Peptides for Cranial Bone Regeneration
10.1002/adhm.201701415 2018-03-02 An ideal synthetic bone graft is a combination of the porous and nanofibrous structure presented by natural bone tissue as well as osteoinductive biochemical factors such as bone morphogenetic protein 2 (BMP‐2). In this work, ultralight 3D hybrid nanofiber ae... |
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Point‐of‐Care Identification of Bacteria Using Protein‐Encapsulated Gold Nanoclusters
10.1002/adhm.201701370 2018-03-02 The rapid, simple, and reliable identification of the most prevalent pathogens is essential for clinical diagnostics, biology, and food safety. Herein, four protein‐encapsulated gold nanoclusters (protein–AuNCs) are designed and prepared as a sensor array for... |
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Therapeutic Nucleic Acids: Advances in Stimulus-Responsive Polymeric Materials for Systemic Delivery of Nucleic Acids (Adv. Healthcare Mater. 4/2018)
10.1002/adhm.201870018 2018-02-21 Polymeric materials responsive to endogenous and exogenous stimuli promise to overcome multitude of barriers faced during systemic delivery of therapeutic nucleic acids. In article number 1701070, David Oupický and co-workers survey successful examples of enh... |
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Antibody-Based Therapeutics: Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)
10.1002/adhm.201870019 2018-02-21 In article number 1700870, Yoon-Sik Lee and co-workers demonstrate in vivo validation process of candidate antibodies against human colon cancer, using a ratiometric quantification method. The validation is performed on a single mouse and analyzed by multiple... |
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Human Tissue Models: Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models (Adv. Healthcare Mater. 4/2018)
10.1002/adhm.201870021 2018-02-21 The use of hydrogel scaffolds for developing in vitro patient-specific tissue and organ models using human-derived cells is a powerful platform for studying the mechanism of disease initiation and progression, screening of potential drug candidates, and ultim... |
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A Capsule‐Type Microrobot with Pick‐and‐Drop Motion for Targeted Drug and Cell Delivery
10.1002/adhm.201700985 2018-02-20 A capsule‐type microrobot exhibits “pick‐and‐drop” (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule‐type microrobot has two parts: a plunger and a cap. The fab... |
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Tropoelastin Implants That Accelerate Wound Repair
10.1002/adhm.201701206 2018-02-16 A novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound ... |
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Multifunctional Cell Instructive Silk‐Bioactive Glass Composite Reinforced Scaffolds Toward Osteoinductive, Proangiogenic, and Resorbable Bone Grafts
10.1002/adhm.201701418 2018-02-14 The successful regeneration of large volume bone defects necessitates the use of proangiogenic and resorbable scaffolding matrix. Impaired and slow ingrowth of host vasculature within implanted grafts greatly compromises its effective osseointegration. By add... |
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Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs
10.1002/adhm.201701393 2018-02-14 Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that often results ... |
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Injectable, Tough Alginate Cryogels as Cancer Vaccines
10.1002/adhm.201701469 2018-02-14 A covalently crosslinked methacrylated (MA)‐alginate cryogel vaccine has been previously shown to generate a potent response against murine melanoma, but is not mechanically robust and requires a large 16G needle for delivery. Here, covalent and ionic crossli... |