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1H NMR metabolic signature of cerebrospinal fluid following repetitive lower-limb remote ischemia preconditioning
10.1016/j.neuint.2018.02.009 2018-02-22 Background Objective The cerebral ischemia/reperfusion greatly influences brain metabolism. Remote ischemia preconditioning (RIPC) is reported to confer neuroprotective effects against cerebral ischemia in animal models and human. This study aims to investiga... |
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Lanthionine ketimine-5-ethyl ester provides neuroprotection in a zebrafish model of okadaic acid-induced Alzheimer's disease
10.1016/j.neuint.2018.02.002 2018-02-21 Okadaic acid (OKA) is a protein phosphatase-2A inhibitor that is used to induce neurodegeneration and study disease states such as Alzheimer's disease (AD). Lanthionine ketimine-5-ethyl ester (LKE) is a bioavailable derivative of the naturally occurring brain... |
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Astaxanthin protects against kainic acid-induced seizures and pathological consequences
10.1016/j.neuint.2018.02.008 2018-02-21 Excitotoxic damage caused by increased glutamate levels is involved in the pathogenesis of neurodegenerative diseases. Astaxanthin, a natural carotenoid with multiple health benefits, inhibits glutamate release from the brain tissue; however, whether it posse... |
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Brain bioenergetics in rats with acute hyperphenylalaninemia ☆
10.1016/j.neuint.2018.01.001 2018-02-14 Phenylketonuria (PKU) is a disorder of phenylalanine (Phe) metabolism caused by deficient phenylalanine hydroxylase activity. The deficiency results in increased levels of Phe and its metabolites in fluids and tissues of patients. PKU patients present neurolo... |
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Cholinergic tone in ventral tegmental area: Functional organization and behavioral implications
10.1016/j.neuint.2018.02.003 2018-02-10 The ventral tegmental area (VTA), a pivotal brain region of the mesocorticolimbic dopaminergic system, is substantially innervated and modulated by cholinergic projections from the pedunculopontine tegmental nucleus and laterodorsal tegmental nucleus. In this... |
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The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases
10.1016/j.neuint.2018.02.006 2018-02-07 Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain ... |
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Alterations of L-type voltage dependent calcium channel alpha 1 subunit in the hippocampal CA3 region during and after pilocarpine-induced epilepsy
10.1016/j.neuint.2018.02.005 2018-02-07 Voltage-dependent calcium channels (VDCC) have been shown to regulate neuronal excitability and their antagonists have been used clinically for the control of seizures. While functional studies of VDCC in epileptogenesis in the CA1 area of hippocampus or the ... |
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New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia
10.1016/j.neuint.2018.01.007 2018-02-02 The brain consists of neurons and much higher number of glial cells. They communicate each other, by which they control brain functions. The brain is highly vulnerable to several insults such as ischemia, but has a self-protective and self-repairing mechanism... |
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A role for KCC3 in maintaining cell volume of peripheral nerve fibers
10.1016/j.neuint.2018.01.009 2018-01-31 The potassium chloride cotransporter, KCC3, is an electroneutral cotransporter expressed in the peripheral and central nervous system. KCC3 is responsible for the efflux of K+ and Cl− in neurons to help maintain cell volume and intracellular chloride levels. ... |
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S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats
10.1016/j.neuint.2018.01.008 2018-01-19 Ischemic stroke, the main reason for severe disabilities in the world, is associated with a high incidence of sensorimotor and cognitive dysfunction. In this study, we use the middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats and oxygen gluc... |