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Architecture of the type IV coupling protein complex of Legionella pneumophila
10.1038/nmicrobiol.2017.114 2017-07-17 Many bacteria, including Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of effector proteins into the hosts for their survival and growth. Type IV coupling protein (T4CP) is a hexameric ATPase that links translocating... |
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Identification and pathological characterization of persistent asymptomatic Ebola virus infection in rhesus monkeys
10.1038/nmicrobiol.2017.113 2017-07-17 Ebola virus (EBOV) persistence in asymptomatic humans and Ebola virus disease (EVD) sequelae have emerged as significant public health concerns since the 2013–2016 EVD outbreak in Western Africa. Until now, studying how EBOV disseminates into and persists in ... |
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Bacteriophage evolution differs by host, lifestyle and genome
10.1038/nmicrobiol.2017.112 2017-07-10 Bacteriophages play key roles in microbial evolution1,2, marine nutrient cycling3 and human disease4. Phages are genetically diverse, and their genome architectures are characteristically mosaic, driven by horizontal gene transfer with other phages and host g... |
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Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses
10.1038/nmicrobiol.2017.101 2017-06-30 Human respiratory syncytial virus (hRSV) is a major cause of morbidity and mortality in the paediatric, elderly and immune-compromised populations1,2. A gap in our understanding of hRSV disease pathology is the interplay between virally encoded immune antagon... |
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ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
10.1038/nmicrobiol.2017.104 2017-06-30 Multidrug-resistant (MDR) bacterial infections are a serious threat to public health. Among the most alarming resistance trends is the rapid rise in the number and diversity of β-lactamases, enzymes that inactivate β-lactams, a class of antibiotics that has b... |
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Vector control gets new impetus and direction
10.1038/nmicrobiol.2017.111 2017-06-27 Vector control gets new impetus and direction Nature Microbiology, Published online: 27 June 2017; doi:10.1038/nmicrobiol.2017.111 The WHO's plans to bolster global vector control measures blend audacious goals with a sensible approach that could save lives a... |
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Host response: Inflammation promotes TB growth
10.1038/nmicrobiol.2017.102 2017-06-27 Host response: Inflammation promotes TB growth Nature Microbiology, Published online: 27 June 2017; doi:10.1038/nmicrobiol.2017.102 Nitric oxide synthase has long been associated with control of Mycobacterium tuberculosis infection. However, new work reveals ... |
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Advocating for vaccination in a climate of science denial
10.1038/nmicrobiol.2017.106 2017-06-27 Advocating for vaccination in a climate of science denial Nature Microbiology, Published online: 27 June 2017; doi:10.1038/nmicrobiol.2017.106 In many countries, the success of misinformation, alternative facts or fake news is promoting a climate of science d... |
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Fungal pathogenesis: Combatting the oxidative burst
10.1038/nmicrobiol.2017.95 2017-06-27 Fungal pathogenesis: Combatting the oxidative burst Nature Microbiology, Published online: 27 June 2017; doi:10.1038/nmicrobiol.2017.95 Plants respond to microbial attack with a lethal burst of reactive oxygen species. How then, do pathogens successfully inva... |
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Metabolism: Built on stable catalysts
10.1038/nmicrobiol.2017.85 2017-06-27 Metabolism: Built on stable catalysts Nature Microbiology, Published online: 27 June 2017; doi:10.1038/nmicrobiol.2017.85 Coenzymes serve as the catalytic core in many metabolic reactions, but despite their extensive use and intrinsic chemical reactivity, the... |