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Aberrant DNA Methylation in Human iPSCs Associates with MYC-Binding Motifs in a Clone-Specific Manner Independent of Genetics
10.1016/j.stem.2017.03.010 2017-04-06 Working as part of the NHLBI NextGen consortium, Panopoulos et al. use iPSCs derived from monozygotic twins to examine factors regulating aberrant CpG methylation. Their findings suggest that aberrant methylation is likely due to a clone-associated biological... |
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Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis
10.1016/j.stem.2017.03.011 2017-04-06 (Cell Stem Cell 20, 261–273; February 2, 2017) |
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RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions
10.1016/j.stem.2017.03.014 2017-04-06 (Cell Stem Cell 20, 462–477; April 6, 2017) |
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Repeal and Replace: Adipocyte Regeneration in Wound Repair
10.1016/j.stem.2017.03.015 2017-04-06 Adipocyte precursor cells generate lipid-filled mature adipocytes in multiple tissues during a high-fat diet and in skin during hair follicle growth. In Science, Plikus et al. report that myofibroblasts can generate lipid-filled adipocytes in large skin wound... |
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lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration
10.1016/j.stem.2017.03.016 2017-04-06 Although prematurely baptized as non-coding, some lncRNAs encode polypeptides with regulatory functions that are implicated in various biological processes. Matsumoto et al. (2017) recently report in Nature that LINC00961 generates SPAR polypeptide that acts ... |
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Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci
10.1016/j.stem.2017.03.017 2017-04-06 Musunuru, Brown, Rader, and colleagues of the NHLBI NextGen consortium use multi-ethnic population cohorts of iPSCs and differentiated hepatocyte-like cells, in combination with mouse models, to discover and validate functional DNA variants and genes at blood... |
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TLRgeting Evasion of Immune Pathways in Glioblastoma
10.1016/j.stem.2017.03.018 2017-04-06 Glioblastoma (GBM) is an intractable brain cancer that presents a strongly immunosuppressive microenvironment. Alvarado et al. now report that GBM cancer stem cells (CSCs) downregulate Toll-like receptor (TLR) 4 to evade immune suppression, and that activatin... |
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“Neural Killer” Cells: Autologous Cytotoxic Neural Stem Cells for Fighting Glioma
10.1016/j.stem.2017.03.019 2017-04-06 Recently in Science Translational Medicine, Bagó et al. reported an advance in treating glioblastoma using tumor-homing cytotoxic induced neural stem cells (h-iNSCTE). This approach circumvents problems associated with immune rejection and minimizes the bench... |
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iPSCs Meet GWAS: The NextGen Consortium
10.1016/j.stem.2017.03.020 2017-04-06 Disease modeling with human iPSCs has come a long way since it first began almost 10 years ago. Many of us can probably remember the time when just making an iPSC line from a patient with a recognized disease was a notable achievement. It didn’t take long, ho... |
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The NextGen Genetic Association Studies Consortium: A Foray into In Vitro Population Genetics
10.1016/j.stem.2017.03.021 2017-04-06 The National Heart, Lung, and Blood Institute’s Next Generation Genetic Association Studies Consortium has used induced pluripotent stem cell technology to study the effects of common genetic variants in vitro. This issue of Cell Stem Cell and affiliated jour... |