|
Muscle Stem Cells Undergo Extensive Clonal Drift during Tissue Growth via Meox1-Mediated Induction of G2 Cell-Cycle Arrest
10.1016/j.stem.2017.06.003 2017-07-06 Organ growth requires a careful balance between stem cell self-renewal and lineage commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that mediate this balance are unresolved in most organs, including skeletal muscle. Here we ... |
|
|
Retinoic Acid Puts Hematopoietic Stem Cells Back To Sleep
10.1016/j.stem.2017.06.002 2017-07-06 Dormant hematopoietic stem cells (dHSCs) display superior serial reconstitution capacity compared to active HSCs, although their role in normal hematopoiesis has not been thoroughly investigated. Recently inCell, Cabezas-Wallscheid et al. (2017) demonstrate i... |
|
|
Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells
10.1016/j.stem.2017.06.001 2017-07-06 Organoid technology holds great potential for disease modeling and regenerative medicine. In this issue ofCell Stem Cell, Múnera et al. (2017) establish the generation of pluripotent stem cell-derived colon organoids that upon transplantation in mice, resembl... |
|
|
Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells
10.1016/j.stem.2017.03.012 2017-07-06 (Cell Stem Cell 12, 407–412; April 4, 2013) |
|
|
Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
10.1016/j.stem.2017.05.020 2017-06-22 Gastric and small intestinal organoids differentiated from human pluripotent stem cells (hPSCs) have revolutionized the study of gastrointestinal development and disease. Distal gut tissues such as cecum and colon, however, have proved considerably more chall... |
|
|
Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State
10.1016/j.stem.2017.05.019 2017-06-22 Direct lineage reprogramming, including with small molecules, has emerged as a promising approach for generating desired cell types. We recently found that during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts, cells pass ... |
|
|
Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells
10.1016/j.stem.2017.05.001 2017-06-22 Replicating Lgr5+stem cells and quiescent Bmi1+cells behave as intestinal stem cells (ISCs) in vivo. Disrupting Lgr5+ISCs triggers epithelial renewal from Bmi1+cells, from secretory or absorptive progenitors, and from Paneth cell precursors, revealing a high ... |
|
|
Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
10.1016/j.stem.2017.04.009 2017-06-08 Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling p... |
|
|
Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma
10.1016/j.stem.2017.04.009 2017-06-08 Haas et al. identify integrin α7 as a functional marker of glioblastoma stem cells by screening a monoclonal antibody library generated against primary glioblastoma (GBM) cells. Functional experiments in culture and in vivo show that the targeting of integrin... |
|
|
The Dynamic Identity of Intestinal Cancer Stem Cells
10.1016/j.stem.2017.05.018 2017-06-01 Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article inNature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC pop... |