| 常用名 | 美登醇 | CAS号 | 57103-68-1 |
|---|---|---|---|
| 价格 | ¥30000.0/1g | 纯度 | 98.0% |
| 备货期 | 80天 | 库存 | 2 g |
| 产品详情(用途,包装等)
用途: Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug. 物理化学性质: CAS号:57103-68-1 常用中文名:美登醇 常用英文名:Maytansinol 分子式:C28H37ClN2O8 分子量:565.055 密度:1.4±0.1 g/cm3 沸点:835.8±65.0 °C at 760 mmHg 熔点:>153C (dec.) 闪点:459.3±34.3 °C 储存条件:2-8℃,惰性气体氛围 |