西咪替丁
更新时间：2025-08-31 17:05:51
| 常用名 | 西咪替丁 | CAS号 | 51481-61-9 |
|---|---|---|---|
| 价格 | ￥需询单/1kg | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 现货 |
| 产品详情（用途，包装等）
用途： Cimetidine is a histamine-2 (H2) receptor antagonist.IC50 Value: Target: Histamine-2 Receptorin vitro: Cimetidine, a partial agonist for H2R, has a pharmacological profile different from ranitidine and famotidine, possibly contributing to its antitumor activity on gastrointestinal cancers [1]. Cimetidine had no effect on the uptake and cytotoxicity of cisplatin in ovarian cancer cells with high OCT2 mRNA levels (IGROV-1 cells) [2]. Cimetidine showed no effect on proliferation, survival, migration and invasion of 3LL cells. Cimetidine reversed MDSC-mediated T-cell suppression, and improved IFN-γ production. [3]. Cimetidine-mediated down-regulation of NCAM involved suppression of the nuclear translocation of NF-kappaB, a transcriptional activator of NCAM gene expression [4].in vivo: the antitumor efficacy of cisplatin in mice bearing luciferase-tagged IGROV-1 xenografts was unaffected by cimetidine (P = 0.39). Data obtained in 18 patients receiving cisplatin (100 mg/m(2)) in a randomized crossover fashion with or without cimetidine (800 mg × 2) revealed that cimetidine did not alter exposure to unbound cisplatin [2]. cimetidine reduced CD11b(+)Gr-1(+) myeloid derived-suppressive cell (MDSC) accumulation in spleen, blood and tumor tissue of tumor-bearing mice [3]. Cimetidine exerts a beneficial effect on periodontal disease in rats, decreasing the RANKL/OPG ratio in gingival connective tissue and reducing alveolar bone resorption [5]. 物理化学性质： CAS号：51481-61-9 常用中文名：西咪替丁 常用英文名：Cimetidine 分子式：C10H16N6S 分子量：252.339 密度：1.3±0.1 g/cm3 沸点：476.2±55.0 °C at 760 mmHg 熔点：139-144°C 闪点：241.8±31.5 °C 储存条件：2-8°C |
- 上海吉至生化科技有限公司
- 上海市 上海市 奉贤区
- 产品名：西咪替丁/西米替汀
- 价格： ￥168.0/100mg
- 纯度：98.0%
- 备货期：需询单
- 联系人：刘佳
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：Cimetidine
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：西咪替丁
- 价格： ￥583.9/100g ￥78.9/1g ￥99.9/5g ￥320.9/25g
- 纯度：99.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$60/1g